5MYG

Crystal structure of the bromodomain of human BRPF1 in complex with NI-57 chemical probe

Summary for 5MYG

• Entry DOI: 10.2210/pdb5myg/pdb
• Descriptor: Peregrin, 4-cyano-~{N}-(1,3-dimethyl-2-oxidanylidene-quinolin-6-yl)-2-methoxy-benzenesulfonamide (3 entities in total)
• Functional Keywords: transcription, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P55201
• Total number of polymer chains: 4
• Total formula weight: 56348.48

Authors

Tallant, C.,Igoe, N.,Bayle, E.D.,Krojer, T.,Nunez-Alonso, G.,Kopec, J.,Fitzpatrick, F.,Savitsky, P.,Fedorov, O.,Brennan, P.E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Fish, P.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-26, release date: 2017-08-09, Last modification date: 2024-01-17)

• Primary citation: Igoe, N.,Bayle, E.D.,Tallant, C.,Fedorov, O.,Meier, J.C.,Savitsky, P.,Rogers, C.,Morias, Y.,Scholze, S.,Boyd, H.,Cunoosamy, D.,Andrews, D.M.,Cheasty, A.,Brennan, P.E.,Muller, S.,Knapp, S.,Fish, P.V.; Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.; J. Med. Chem., 60:6998-7011, 2017; PubMed: 28714688; DOI: 10.1021/acs.jmedchem.7b00611

Experimental method

X-RAY DIFFRACTION (2.3 Å)