8PJ7

MLLT3 in complex with compound PFI-6

Summary for 8PJ7

Entry DOI	10.2210/pdb8pj7/pdb
Descriptor	Protein AF-9, ~{N}-[(1~{R})-2,3-dihydro-1~{H}-inden-1-yl]-5-[4-(dimethylcarbamoyl)-3-oxidanyl-phenyl]-1,2-oxazole-3-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	complex inhibitor, peptide binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	18394.97
Authors	Raux, B.,Diaz-Saez, L.,Huber, K.V.M.,Fedorov, O.,Owen, D.R.,Londregan, A.T.,Bountra, C.,Edwards, A.,Arrowsmith, C. (deposition date: 2023-06-22, release date: 2023-11-22, Last modification date: 2023-12-27)
Primary citation	Raux, B.,Buchan, K.A.,Bennett, J.,Christott, T.,Dowling, M.S.,Farnie, G.,Fedorov, O.,Gamble, V.,Gileadi, C.,Giroud, C.,Huber, K.V.M.,Korczynska, M.,Limberakis, C.,Narayanan, A.,Owen, D.R.,Saez, L.D.,Stock, I.A.,Londregan, A.T. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98:129546-129546, 2023 Cited by PubMed: 37944866 DOI: 10.1016/j.bmcl.2023.129546 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.26 Å)

Structure validation