8PJ7
MLLT3 in complex with compound PFI-6
Summary for 8PJ7
Entry DOI | 10.2210/pdb8pj7/pdb |
Descriptor | Protein AF-9, ~{N}-[(1~{R})-2,3-dihydro-1~{H}-inden-1-yl]-5-[4-(dimethylcarbamoyl)-3-oxidanyl-phenyl]-1,2-oxazole-3-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | complex inhibitor, peptide binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18394.97 |
Authors | Raux, B.,Diaz-Saez, L.,Huber, K.V.M.,Fedorov, O.,Owen, D.R.,Londregan, A.T.,Bountra, C.,Edwards, A.,Arrowsmith, C. (deposition date: 2023-06-22, release date: 2023-11-22, Last modification date: 2023-12-27) |
Primary citation | Raux, B.,Buchan, K.A.,Bennett, J.,Christott, T.,Dowling, M.S.,Farnie, G.,Fedorov, O.,Gamble, V.,Gileadi, C.,Giroud, C.,Huber, K.V.M.,Korczynska, M.,Limberakis, C.,Narayanan, A.,Owen, D.R.,Saez, L.D.,Stock, I.A.,Londregan, A.T. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98:129546-129546, 2023 Cited by PubMed: 37944866DOI: 10.1016/j.bmcl.2023.129546 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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