Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2VAG

Crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor

Summary for 2VAG
Entry DOI10.2210/pdb2vag/pdb
Related1Z57
DescriptorDUAL SPECIFICITY PROTEIN KINASE CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate (3 entities in total)
Functional Keywordsserine/threonine-protein kinase, tyrosine-protein kinase, nucleus, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus: P49759
Total number of polymer chains1
Total formula weight40079.66
Authors
Pike, A.C.W.,Bullock, A.N.,Fedorov, O.,Pilka, E.S.,Ugochukwu, E.,von Delft, F.,Edwards, A.,Arrowsmith, C.H.,Weigelt, J.,Sundstrom, M.,Huber, K.,Bracher, F.,Knapp, S. (deposition date: 2007-08-31, release date: 2007-10-09, Last modification date: 2023-12-13)
Primary citationFedorov, O.,Huber, K.,Eisenreich, A.,Filippakopoulos, P.,King, O.,Bullock, A.N.,Szklarczyk, D.,Jensen, L.J.,Fabbro, D.,Trappe, J.,Rauch, U.,Bracher, F.,Knapp, S.
Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
Chem.Biol, 18:67-, 2011
Cited by
PubMed: 21276940
DOI: 10.1016/J.CHEMBIOL.2010.11.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon