2VAG
Crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DUAL SPECIFICITY PROTEIN KINASE CLK1 | polymer | 339 | 39741.5 | 1 | UniProt (P49759) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CDC-LIKE KINASE 1 |
| 2 | B (A) | ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | non-polymer | 338.2 | 1 | Chemie (V25) | |||
| 3 | C (A) | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 432 | Arg 432 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39741.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 338.2 | |
| All* | Total formula weight | 40079.7 |
