1Z57

Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine

Summary for 1Z57

Entry DOI	10.2210/pdb1z57/pdb
Related	1jow
Descriptor	Dual specificity protein kinase CLK1, DEBROMOHYMENIALDISINE (3 entities in total)
Functional Keywords	protein tyrosine kinase, dual specificity, splicing, human, 10z-hymendialdisine, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P49759
Total number of polymer chains	1
Total formula weight	39826.75
Authors	Debreczeni, J.,Das, S.,Knapp, S.,Bullock, A.,Guo, K.,Amos, A.,Fedorov, O.,Edwards, A.,Sundstrom, M.,von Delft, F.,Niesen, F.H.,Ball, L.,Sobott, F.,Arrowsmith, C.,Structural Genomics Consortium (SGC) (deposition date: 2005-03-17, release date: 2005-04-12, Last modification date: 2023-08-23)
Primary citation	Bullock, A.N.,Das, S.,Debreczeni, J.E.,Rellos, P.,Fedorov, O.,Niesen, F.H.,Guo, K.,Papagrigoriou, E.,Amos, A.L.,Cho, S.,Turk, B.E.,Ghosh, G.,Knapp, S. Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure, 17:352-362, 2009 Cited by PubMed: 19278650 DOI: 10.1016/j.str.2008.12.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation