4Z6I

Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand

Summary for 4Z6I

• Entry DOI: 10.2210/pdb4z6i/pdb
• Descriptor: Bromodomain-containing protein 9, tert-butyl [(2R,3S)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxo-2-phenylpiperidin-3-yl]carbamate (3 entities in total)
• Functional Keywords: lysine-acetylated histone binding, chromatin regulator, transcription, bromodomain, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29422.63

Authors

Tallant, C.,Structural Genomics Consortium (SGC),Clark, P.G.K.,Vieira, L.C.C.,Newman, J.A.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Fedorov, O.,Dixon, D.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S. (deposition date: 2015-04-05, release date: 2015-05-20, Last modification date: 2024-01-10)

• Primary citation: Clark, P.G.,Vieira, L.C.,Tallant, C.,Fedorov, O.,Singleton, D.C.,Rogers, C.M.,Monteiro, O.P.,Bennett, J.M.,Baronio, R.,Muller, S.,Daniels, D.L.,Mendez, J.,Knapp, S.,Brennan, P.E.,Dixon, D.J.; LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.; Angew.Chem.Int.Ed.Engl., 54:6217-6221, 2015; PubMed: 25864491; DOI: 10.1002/anie.201501394

Experimental method

X-RAY DIFFRACTION (1.95 Å)