4Z6I
Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 4L3 A 201 |
| Chain | Residue |
| A | HIS42 |
| A | GLY43 |
| A | PHE44 |
| A | PHE47 |
| A | PRO48 |
| A | ALA54 |
| A | ASN100 |
| A | TYR106 |
| A | HOH310 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue 4L3 B 201 |
| Chain | Residue |
| B | HIS42 |
| B | GLY43 |
| B | PHE44 |
| B | PHE45 |
| B | PHE47 |
| B | PRO48 |
| B | ASN100 |
| B | TYR106 |
| B | HOH308 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding => ECO:0000269|PubMed:26365797 |
| Chain | Residue | Details |
| A | ILE53 | |
| A | TYR106 | |
| B | ILE53 | |
| B | TYR106 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q3UQU0 |
| Chain | Residue | Details |
| A | GLY56 | |
| B | GLY56 |
