4Z6I
Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Bromodomain-containing protein 9 | polymer | 123 | 14249.8 | 2 | UniProt (Q9H8M2) Pfam (PF00439) In PDB | Homo sapiens (Human) | Rhabdomyosarcoma antigen MU-RMS-40.8 |
2 | A, B | tert-butyl [(2R,3S)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxo-2-phenylpiperidin-3-yl]carbamate | non-polymer | 461.6 | 2 | Chemie (4L3) | |||
3 | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, B: 14 - 134 (UniProt: Q9H8M2)
PDB | External Database | Details |
---|---|---|
Ser 12 | - | expression tag |
Met 13 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 28499.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 923.1 | |
All* | Total formula weight | 29422.6 |