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1AQ1
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BU of 1aq1 by Molmil
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Descriptor: CYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE
Authors:Endicott, J.A, Noble, M.E.M, Johnson, L.N, Lawrie, A, Tunnah, P, Brown, N.R.
Deposit date:1997-08-05
Release date:1997-11-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat.Struct.Biol., 4, 1997
1E1V
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BU of 1e1v by Molmil
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058
Descriptor: 6-O-CYCLOHEXYLMETHYL GUANINE, CYCLIN-DEPENDENT PROTEIN KINASE 2
Authors:Endicott, J.A, Noble, M.E.M, Johnson, L.N.
Deposit date:2000-05-11
Release date:2001-05-10
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.
J.Med.Chem., 43, 2000
1E1X
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BU of 1e1x by Molmil
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027
Descriptor: 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE, CYCLIN-DEPENDENT PROTEIN KINASE 2
Authors:Endicott, J.A, Noble, M.E.M, Johnson, L.N.
Deposit date:2000-05-11
Release date:2001-05-10
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.
J.Med.Chem., 43, 2000
8ROZ
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BU of 8roz by Molmil
Cryo-EM structure of CDK2-cyclin A in complex with CDC25A
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2, M-phase inducer phosphatase 1
Authors:Rowland, R.J, Noble, M.E.M, Endicott, J.A.
Deposit date:2024-01-12
Release date:2024-05-29
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structure of the CDK2-cyclin A-CDC25A complex.
Nat Commun, 15, 2024
3DDQ
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BU of 3ddq by Molmil
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
Descriptor: Cell division protein kinase 2, Cyclin-A2, MONOTHIOGLYCEROL, ...
Authors:Echalier, A, Endicott, J.A.
Deposit date:2008-06-06
Release date:2008-07-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Oncogene, 27, 2008
5CYI
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BU of 5cyi by Molmil
CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)
Descriptor: 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Anscombe, E, Meschini, E, Vidal, R.M, Martin, M.P, Staunton, D, Geitmann, M, Danielson, U.H, Stanley, W.A, Wang, L.Z, Reuillon, T, Golding, B.T, Cano, C, Newell, D.R, Noble, M.E.M, Wedge, S.R, Endicott, J.A, Griffin, R.J.
Deposit date:2015-07-30
Release date:2015-09-16
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and Characterization of an Irreversible Inhibitor of CDK2.
Chem.Biol., 22, 2015
7OXW
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BU of 7oxw by Molmil
CrabP2 mutant R30DK31D
Descriptor: ACETATE ION, Cellular retinoic acid-binding protein 2, SULFATE ION
Authors:Pastok, M.W, Basle, A, Endicott, J.A.
Deposit date:2021-06-23
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Structural requirements for the specific binding of CRABP2 to cyclin D3
To Be Published
7OZT
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BU of 7ozt by Molmil
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
Descriptor: Camelid nanobody NB09, Cyclin-dependent kinase inhibitor 2A
Authors:Pastok, M.W, Burbidge, O, Itzhaki, L, Endicott, J.A, Noble, M.E.M.
Deposit date:2021-06-28
Release date:2022-07-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
To Be Published
4Y72
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BU of 4y72 by Molmil
Human CDK1/CyclinB1/CKS2 With Inhibitor
Descriptor: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ...
Authors:Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
Deposit date:2015-02-13
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC3
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BU of 4yc3 by Molmil
CDK1/CyclinB1/CKS2 Apo
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
Deposit date:2015-02-19
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC6
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BU of 4yc6 by Molmil
CDK1/CKS1
Descriptor: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1
Authors:Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
Deposit date:2015-02-19
Release date:2015-05-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
9ET1
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BU of 9et1 by Molmil
CDK2-cyclin A in complex with FragLite 12
Descriptor: 4-iodanylbenzamide, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ESO
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BU of 9eso by Molmil
CDK2-cyclin A in complex with FragLite 27
Descriptor: (4-bromo-1H-pyrazol-1-yl)acetic acid, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ET4
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BU of 9et4 by Molmil
CDK2-cyclin A in complex with FragLite 9
Descriptor: 4-iodanylbenzenesulfonamide, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.641 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ETB
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BU of 9etb by Molmil
CDK2-cyclin A in complex with FragLite 2
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-IODOPYRAZOLE, Cyclin-A2, ...
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ET3
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BU of 9et3 by Molmil
CDK2-cyclin A in complex with FragLite 10
Descriptor: 6-bromo-1,3-dihydro-2H-indol-2-one, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ET9
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BU of 9et9 by Molmil
CDK2-cyclin A in complex with FragLite 4
Descriptor: 4-bromanylpyridin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ESK
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BU of 9esk by Molmil
CDK2-cyclin A in complex with FragLite 30
Descriptor: (4-bromo-2-oxopyridin-1(2H)-yl)acetic acid, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ETA
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BU of 9eta by Molmil
CDK2-cyclin A in complex with FragLite 3
Descriptor: 4-bromanyl-1,2-oxazole, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.512 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ESN
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BU of 9esn by Molmil
CDK2-cyclin A in complex with FragLite 28
Descriptor: 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ESX
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BU of 9esx by Molmil
CDK2-cyclin A in complex with FragLite 17
Descriptor: 1-bromanyl-4-methylsulfonyl-benzene, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ESJ
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BU of 9esj by Molmil
CDK2-cyclin A in complex with FragLite 31
Descriptor: 2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ESS
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BU of 9ess by Molmil
CDK2-cyclin A in complex with FragLite 22
Descriptor: (4-bromo-2-methoxyphenyl)methanol, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ESU
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BU of 9esu by Molmil
CDK2-cyclin A in complex with FragLite 20
Descriptor: 4-bromanyl-2-(methoxymethyl)pyridine, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
9ET6
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BU of 9et6 by Molmil
CDK2-cyclin A in complex with FragLite 7
Descriptor: 4-iodanyl-3~{H}-pyridin-2-one, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J.
Deposit date:2024-03-26
Release date:2025-04-09
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published

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