1AQ1
 
 | | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE | | Descriptor: | CYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE | | Authors: | Endicott, J.A, Noble, M.E.M, Johnson, L.N, Lawrie, A, Tunnah, P, Brown, N.R. | | Deposit date: | 1997-08-05 | | Release date: | 1997-11-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat.Struct.Biol., 4, 1997
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1E1V
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1E1X
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8ROZ
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3DDQ
 | | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine | | Descriptor: | Cell division protein kinase 2, Cyclin-A2, MONOTHIOGLYCEROL, ... | | Authors: | Echalier, A, Endicott, J.A. | | Deposit date: | 2008-06-06 | | Release date: | 2008-07-22 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Oncogene, 27, 2008
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5CYI
 | | CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300) | | Descriptor: | 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Anscombe, E, Meschini, E, Vidal, R.M, Martin, M.P, Staunton, D, Geitmann, M, Danielson, U.H, Stanley, W.A, Wang, L.Z, Reuillon, T, Golding, B.T, Cano, C, Newell, D.R, Noble, M.E.M, Wedge, S.R, Endicott, J.A, Griffin, R.J. | | Deposit date: | 2015-07-30 | | Release date: | 2015-09-16 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Identification and Characterization of an Irreversible Inhibitor of CDK2.
Chem.Biol., 22, 2015
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7OXW
 | | CrabP2 mutant R30DK31D | | Descriptor: | ACETATE ION, Cellular retinoic acid-binding protein 2, SULFATE ION | | Authors: | Pastok, M.W, Basle, A, Endicott, J.A. | | Deposit date: | 2021-06-23 | | Release date: | 2022-07-13 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.16 Å) | | Cite: | Structural requirements for the specific binding of CRABP2 to cyclin D3
To Be Published
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7OZT
 | | Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a | | Descriptor: | Camelid nanobody NB09, Cyclin-dependent kinase inhibitor 2A | | Authors: | Pastok, M.W, Burbidge, O, Itzhaki, L, Endicott, J.A, Noble, M.E.M. | | Deposit date: | 2021-06-28 | | Release date: | 2022-07-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
To Be Published
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4Y72
 | | Human CDK1/CyclinB1/CKS2 With Inhibitor | | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... | | Authors: | Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. | | Deposit date: | 2015-02-13 | | Release date: | 2015-08-12 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
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4YC3
 | | CDK1/CyclinB1/CKS2 Apo | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ... | | Authors: | Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. | | Deposit date: | 2015-02-19 | | Release date: | 2016-04-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
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4YC6
 | | CDK1/CKS1 | | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1 | | Authors: | Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. | | Deposit date: | 2015-02-19 | | Release date: | 2015-05-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
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9ET1
 | | CDK2-cyclin A in complex with FragLite 12 | | Descriptor: | 4-iodanylbenzamide, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.394 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESO
 | | CDK2-cyclin A in complex with FragLite 27 | | Descriptor: | (4-bromo-1H-pyrazol-1-yl)acetic acid, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET4
 | | CDK2-cyclin A in complex with FragLite 9 | | Descriptor: | 4-iodanylbenzenesulfonamide, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.641 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ETB
 | | CDK2-cyclin A in complex with FragLite 2 | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-IODOPYRAZOLE, Cyclin-A2, ... | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET3
 | | CDK2-cyclin A in complex with FragLite 10 | | Descriptor: | 6-bromo-1,3-dihydro-2H-indol-2-one, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET9
 | | CDK2-cyclin A in complex with FragLite 4 | | Descriptor: | 4-bromanylpyridin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.494 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESK
 | | CDK2-cyclin A in complex with FragLite 30 | | Descriptor: | (4-bromo-2-oxopyridin-1(2H)-yl)acetic acid, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.398 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ETA
 | | CDK2-cyclin A in complex with FragLite 3 | | Descriptor: | 4-bromanyl-1,2-oxazole, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.512 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESN
 | | CDK2-cyclin A in complex with FragLite 28 | | Descriptor: | 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.393 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESX
 | | CDK2-cyclin A in complex with FragLite 17 | | Descriptor: | 1-bromanyl-4-methylsulfonyl-benzene, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESJ
 | | CDK2-cyclin A in complex with FragLite 31 | | Descriptor: | 2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESS
 | | CDK2-cyclin A in complex with FragLite 22 | | Descriptor: | (4-bromo-2-methoxyphenyl)methanol, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESU
 | | CDK2-cyclin A in complex with FragLite 20 | | Descriptor: | 4-bromanyl-2-(methoxymethyl)pyridine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET6
 | | CDK2-cyclin A in complex with FragLite 7 | | Descriptor: | 4-iodanyl-3~{H}-pyridin-2-one, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.553 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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