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1UMW
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BU of 1umw by Molmil
Structure of a human Plk1 Polo-box domain/phosphopeptide complex
Descriptor: PEPTIDE, SERINE/THREONINE-PROTEIN KINASE PLK
Authors:Rellos, P, Elia, A, Yaffe, M.B, Smerdon, S.J.
Deposit date:2003-08-29
Release date:2003-10-16
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
Cell(Cambridge,Mass.), 115, 2003
4PN7
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BU of 4pn7 by Molmil
Crystal Structure of the TFIIH p34 N-terminal Domain
Descriptor: Putative transcription factor
Authors:Schmitt, D.R, Kuper, J, Elias, A, Kisker, C.
Deposit date:2014-05-23
Release date:2014-07-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:The Structure of the TFIIH p34 Subunit Reveals a Von Willebrand Factor A Like Fold.
Plos One, 9, 2014
4LTE
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BU of 4lte by Molmil
Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor
Descriptor: 2,6-DIAMINO-HEXANOIC ACID AMIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FUMARIC ACID, ...
Authors:Foda, Z.H, Seeliger, M.A, Saghatelian, A, Liu, D.R.
Deposit date:2013-07-23
Release date:2014-05-21
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.705 Å)
Cite:Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
Nature, 511, 2014
7MRJ
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BU of 7mrj by Molmil
Crystal structure of a novel ubiquitin-like TINCR
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Forouhar, F, Morgado-Palacin, L, Brown, J.A, Martinez, T, Pedrero, J.M.G, Reglero, C, Chaudhry, I, Vaughan, J, Rodriguez-Perales, S, Allonca, E, Granda-Diaz, R, Quinn, S.A, Fernandez, A.F, Fraga, M.F, Kim, A.L, Santos-Juanes, J, Owens, D.M, Rodrigo, J.P, Saghatelian, A, Ferrando, A.A.
Deposit date:2021-05-07
Release date:2022-03-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma.
Nat Commun, 14, 2023
3OV6
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BU of 3ov6 by Molmil
CD1c in complex with MPM (mannosyl-beta1-phosphomycoketide)
Descriptor: 1-O-[(S)-hydroxy{[(4S,8S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-beta-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ...
Authors:Scharf, L, Li, N.S, Hawk, A.J, Garzon, D, Zhang, T, Kazen, A.R, Shah, S, Haddadian, E.J, Saghatelian, A, Faraldo-Gomez, J.D, Meredith, S.C, Piccirilli, J.A, Adams, E.J.
Deposit date:2010-09-15
Release date:2011-01-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:The 2.5 A structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation
Immunity, 33, 2010
4L9L
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BU of 4l9l by Molmil
Crystal structure of a human Valpha7.2/Vbeta13.2 MAIT TCR in complex with bovine MR1
Descriptor: Beta-2-microglobulin, MHC class I-related protein, Human MAIT TCR alpha chain, ...
Authors:Lopez-Sagaseta, J, Adams, E.J.
Deposit date:2013-06-18
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1.
J.Immunol., 191, 2013
6T0L
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BU of 6t0l by Molmil
Crystal structure of CYP124 in complex with inhibitor compound 5'
Descriptor: CHLORIDE ION, CYP124 in complex with inhibitor compound 5', DI(HYDROXYETHYL)ETHER, ...
Authors:Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V.
Deposit date:2019-10-03
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.
J.Mol.Biol., 433, 2021
6T0G
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BU of 6t0g by Molmil
Crystal structure of CYP124 in complex with vitamin D3
Descriptor: (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL, MAGNESIUM ION, Methyl-branched lipid omega-hydroxylase, ...
Authors:Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V.
Deposit date:2019-10-03
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.
J.Mol.Biol., 433, 2021
6T0F
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BU of 6t0f by Molmil
Crystal structure of CYP124 in complex with cholest-4-en-3-one
Descriptor: (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, ...
Authors:Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V.
Deposit date:2019-10-03
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.
J.Mol.Biol., 433, 2021
6T0H
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BU of 6t0h by Molmil
Crystal structure of CYP124 in complex with 1-alpha-hydroxy-vitamin D3
Descriptor: 1-alpha-hydroxy-vitamin D3, CHLORIDE ION, CYP124 in complex with inhibitor carbethoxyhexyl imidazole, ...
Authors:Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V.
Deposit date:2019-10-03
Release date:2020-10-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.
J.Mol.Biol., 433, 2021
6T0K
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BU of 6t0k by Molmil
Crystal structure of CYP124 in complex with inhibitor carbethoxyhexyl imidazole
Descriptor: CHLORIDE ION, CYP124 in complex with inhibitor carbethoxyhexyl imidazole, GLYCEROL, ...
Authors:Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V.
Deposit date:2019-10-03
Release date:2020-10-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.
J.Mol.Biol., 433, 2021
6MQ3
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BU of 6mq3 by Molmil
Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocycle Inhibitor 63
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-degrading enzyme, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol
Authors:Tan, G.A, Seeliger, M.A, Welsh, A.J, Maianti, J.P, Liu, D.R.
Deposit date:2018-10-09
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.569147 Å)
Cite:Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat.Chem.Biol., 15, 2019
3ETF
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BU of 3etf by Molmil
Crystal structure of a putative succinate-semialdehyde dehydrogenase from salmonella typhimurium lt2
Descriptor: Putative succinate-semialdehyde dehydrogenase
Authors:Brunzelle, J.S, Evdokimova, E, Kudritska, M, Wawrzak, Z, Anderson, W.F, Savchenk, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2008-10-07
Release date:2008-11-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and activity of the NAD(P)(+) -dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.
Proteins, 81, 2013
7T9I
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BU of 7t9i by Molmil
Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2021-12-19
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
7T9N
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BU of 7t9n by Molmil
M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2021-12-19
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
7T9M
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BU of 7t9m by Molmil
Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS-17 Heavy Chain, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2021-12-19
Release date:2022-08-10
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
3EFV
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BU of 3efv by Molmil
Crystal Structure of a Putative Succinate-Semialdehyde Dehydrogenase from Salmonella typhimurium LT2 with bound NAD
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative succinate-semialdehyde dehydrogenase
Authors:Brunzelle, J.S, Evdokimova, E, Kudritska, M, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2008-09-10
Release date:2008-11-04
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and activity of the NAD(P)(+) -dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.
Proteins, 81, 2013
7UTZ
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BU of 7utz by Molmil
Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2022-04-28
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
6XXU
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BU of 6xxu by Molmil
Solution NMR structure of the native form of UbcH7 (UBE2L3)
Descriptor: Ubiquitin-conjugating enzyme E2 L3
Authors:Marousis, K.D, Seliami, A, Birkou, M, Episkopou, V, Spyroulias, G.A.
Deposit date:2020-01-28
Release date:2020-02-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:1H,13C,15N backbone and side-chain resonance assignment of the native form of UbcH7 (UBE2L3) through solution NMR spectroscopy.
Biomol.Nmr Assign., 14, 2020
6EDS
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BU of 6eds by Molmil
Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63
Descriptor: 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Tan, G.A, Seeliger, M.A, Maianti, J.P, Liu, D.R, Welsh, A.J.
Deposit date:2018-08-10
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.18071723 Å)
Cite:Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat.Chem.Biol., 15, 2019
4IIQ
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BU of 4iiq by Molmil
Crystal structure of a human MAIT TCR in complex with bovine MR1
Descriptor: Beta-2-microglobulin, MHC class I-related protein, Human Mucosal Associated Invariant T cell receptor alpha chain, ...
Authors:Lopez-Sagaseta, J, Adams, E.J.
Deposit date:2012-12-20
Release date:2013-04-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LCC
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BU of 4lcc by Molmil
Crystal structure of a human MAIT TCR in complex with a bacterial antigen bound to humanized bovine MR1
Descriptor: 1-deoxy-1-[6-(hydroxymethyl)-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl]-D-arabinitol, Beta-2-microglobulin, MHC class I-related protein, ...
Authors:Lopez-Sagaseta, J, Adams, E.J.
Deposit date:2013-06-21
Release date:2013-10-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.263 Å)
Cite:MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1.
J.Immunol., 191, 2013
4L8S
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BU of 4l8s by Molmil
Crystal structure of a human Valpha7.2/Vbeta13.3 MAIT TCR in complex with bovine MR1
Descriptor: Beta-2-microglobulin, MHC class I-related protein, Muccosal Associated Invariant T Cell Receptor alpha chain, ...
Authors:Lopez-Sagaseta, J, Adams, E.J.
Deposit date:2013-06-17
Release date:2013-10-16
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1.
J.Immunol., 191, 2013

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