6T0G

Crystal structure of CYP124 in complex with vitamin D3

Summary for 6T0G

• Entry DOI: 10.2210/pdb6t0g/pdb
• Descriptor: Methyl-branched lipid omega-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL, ... (6 entities in total)
• Functional Keywords: cytochrome, p450, cyp, oxidoreductase, vitamind3, d3, vitamin, 124, cyp124, cholecalciferol, calciferol, tuberculosis, mycobacterium tuberculosis
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 50189.01

Authors

Bukhdruker, S.,Marin, E.,Varaksa, T.,Gilep, A.,Strushkevich, N.,Borshchevskiy, V. (deposition date: 2019-10-03, release date: 2020-10-14, Last modification date: 2024-01-24)

• Primary citation: Varaksa, T.,Bukhdruker, S.,Grabovec, I.,Marin, E.,Kavaleuski, A.,Gusach, A.,Kovalev, K.,Maslov, I.,Luginina, A.,Zabelskii, D.,Astashkin, R.,Shevtsov, M.,Smolskaya, S.,Kavaleuskaya, A.,Shabunya, P.,Baranovsky, A.,Dolgopalets, V.,Charnou, Y.,Savachka, A.,Litvinovskaya, R.,Hurski, A.,Shevchenko, E.,Rogachev, A.,Mishin, A.,Gordeliy, V.,Gabrielian, A.,Hurt, D.E.,Nikonenko, B.,Majorov, K.,Apt, A.,Rosenthal, A.,Gilep, A.,Borshchevskiy, V.,Strushkevich, N.; Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.; J.Mol.Biol., 433:166763-166763, 2021; PubMed: 33359098; DOI: 10.1016/j.jmb.2020.166763

Experimental method

X-RAY DIFFRACTION (1.3 Å)