6T0G
Crystal structure of CYP124 in complex with vitamin D3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methyl-branched lipid omega-hydroxylase | polymer | 435 | 48838.9 | 1 | UniProt (P9WPP3) Pfam (PF00067) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Cholest-4-en-3-one C26-monooxygenase,Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming],Cholesterol C26-monooxygenase,Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming],Cytochrome P450 124,Steroid C26-monooxygenase,Steroid C27-monooxygenase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL | non-polymer | 384.6 | 1 | Chemie (VD3) PubChem (20849436) PubChem (22811020) PubChem (24779639) PubChem (25057171) PubChem (25127095) PubChem (25245915) PubChem (25749216) PubChem (25749217) PubChem (177472622) PubChem (25886212) PubChem (17756775) PubChem (25203321) PubChem (25886211) PubChem (40976976) PubChem (40467764) PubChem (42051934) PubChem (42051935) PubChem (44120164) PubChem (54254000) PubChem (44281724) PubChem (57484195) PubChem (46783253) PubChem (71772573) PubChem (87058084) PubChem (88100830) PubChem (5280795) PubChem (50990069) PubChem (51398172) PubChem (51398173) PubChem (51412568) PubChem (51412569) PubChem (6451358) PubChem (54253997) PubChem (54253998) PubChem (54253999) PubChem (54254001) PubChem (12303091) PubChem (12303110) PubChem (57853712) PubChem (162855011) PubChem (59105885) PubChem (66509018) PubChem (73891144) PubChem (73946685) PubChem (88558217) PubChem (88929345) PubChem (89154175) PubChem (89690182) PubChem (90889268) PubChem (91463052) PubChem (2735) PubChem (6221) PubChem (123256248) PubChem (123977226) PubChem (1548920) PubChem (1548921) PubChem (1548922) PubChem (1548923) PubChem (5283710) PubChem (5283711) PubChem (5283712) PubChem (5353527) PubChem (5363362) PubChem (6393768) PubChem (6432644) PubChem (6604201) PubChem (6604662) PubChem (6708595) PubChem (6713938) PubChem (6992015) PubChem (6992016) PubChem (7067439) PubChem (7067440) PubChem (129009980) PubChem (129010296) PubChem (7251172) PubChem (7251174) PubChem (9821465) PubChem (10000117) PubChem (10340013) PubChem (10883523) PubChem (11463269) PubChem (129627856) PubChem (12303085) PubChem (12303090) PubChem (12303092) PubChem (12303099) PubChem (12303103) PubChem (12303106) PubChem (12303109) PubChem (135221919) PubChem (135391163) PubChem (139407593) PubChem (162855012) PubChem (171607091) PubChem (173204885) PubChem (173481552) PubChem (173519658) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | F, G (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 6 | H (A) | water | water | 18.0 | 748 | Chemie (HOH) |
Sequence modifications
A: 1 - 428 (UniProt: P9WPP3)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48838.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1350.1 | |
| All* | Total formula weight | 50189.0 |
