6T0G
Crystal structure of CYP124 in complex with vitamin D3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0010430 | biological_process | fatty acid omega-oxidation |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0031073 | molecular_function | cholesterol 26-hydroxylase activity |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070402 | molecular_function | NADPH binding |
| A | 0097089 | biological_process | methyl-branched fatty acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | ILE111 |
| A | ARG320 |
| A | TYR343 |
| A | GLY370 |
| A | PHE371 |
| A | GLY372 |
| A | HIS377 |
| A | CYS379 |
| A | GLY381 |
| A | VD3502 |
| A | HOH685 |
| A | HIS118 |
| A | HOH740 |
| A | HOH742 |
| A | HOH807 |
| A | ARG122 |
| A | LEU264 |
| A | ALA267 |
| A | GLY268 |
| A | THR271 |
| A | THR272 |
| A | VAL315 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue VD3 A 502 |
| Chain | Residue |
| A | ASN93 |
| A | THR95 |
| A | ILE197 |
| A | HEM501 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | HOH752 |
| A | HOH816 |
| A | HOH1071 |
| A | HOH1110 |
| A | HOH1288 |
| A | HOH1314 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 504 |
| Chain | Residue |
| A | HOH663 |
| A | HOH728 |
| A | HOH1093 |
| A | HOH1113 |
| A | HOH1229 |
| A | HOH1324 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PGE A 505 |
| Chain | Residue |
| A | HIS84 |
| A | PRO85 |
| A | ASP86 |
| A | ILE87 |
| A | PGE506 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue PGE A 506 |
| Chain | Residue |
| A | HIS84 |
| A | ILE87 |
| A | PGE505 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"19933331","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WM5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
