1JBU
 
 | Coagulation Factor VII Zymogen (EGF2/Protease) in Complex with Inhibitory Exosite Peptide A-183 | Descriptor: | BENZAMIDINE, COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, ... | Authors: | Eigenbrot, C, Kirchhofer, D, Dennis, M.S, Santell, L, Lazarus, R.A, Stamos, J, Ultsch, M.H. | Deposit date: | 2001-06-06 | Release date: | 2001-07-11 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The factor VII zymogen structure reveals reregistration of beta strands during activation. Structure, 9, 2001
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6RLX
 
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1AAL
 
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7PTI
 
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2FGW
 
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3MZW
 
 | HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin G-binding protein A, ... | Authors: | Eigenbrot, C, Ultsch, M.H. | Deposit date: | 2010-05-13 | Release date: | 2010-07-28 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for high-affinity HER2 receptor binding by an engineered protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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3TJN
 
 | HtrA1 catalytic domain, apo form | Descriptor: | Serine protease HTRA1 | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2011-08-24 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and Functional Analysis of HtrA1 and Its Subdomains. Structure, 20, 2012
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3TJQ
 
 | N-domain of HtrA1 | Descriptor: | CHLORIDE ION, GLYCEROL, PLATINUM (II) ION, ... | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2011-08-24 | Release date: | 2012-05-16 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural and Functional Analysis of HtrA1 and Its Subdomains. Structure, 20, 2012
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3TJO
 
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1ICW
 
 | INTERLEUKIN-8, MUTANT WITH GLU 38 REPLACED BY CYS AND CYS 50 REPLACED BY ALA | Descriptor: | INTERLEUKIN-8 | Authors: | Eigenbrot, C, Lowman, H.B, Chee, L, Artis, D.R. | Deposit date: | 1996-09-18 | Release date: | 1997-03-12 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of E38C/C50AIL-8 at 2 A resolution. Proteins, 27, 1997
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1AGQ
 
 | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT | Descriptor: | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR | Authors: | Eigenbrot, C, Gerber, N. | Deposit date: | 1997-03-25 | Release date: | 1997-06-05 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nat.Struct.Biol., 4, 1997
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1FVC
 
 | X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING | Descriptor: | IGG1-KAPPA 4D5 FV (HEAVY CHAIN), IGG1-KAPPA 4D5 FV (LIGHT CHAIN) | Authors: | Eigenbrot, C, Randal, M, Kossiakoff, A.A, Presta, L. | Deposit date: | 1992-10-20 | Release date: | 1993-10-31 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J.Mol.Biol., 229, 1993
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1FVE
 
 | X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING | Descriptor: | IGG1-KAPPA 4D5 FAB (HEAVY CHAIN), IGG1-KAPPA 4D5 FAB (LIGHT CHAIN) | Authors: | Eigenbrot, C, Randal, M, Presta, L, Kossiakoff, A.A. | Deposit date: | 1992-10-20 | Release date: | 1993-10-31 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J.Mol.Biol., 229, 1993
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1FVD
 
 | X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING | Descriptor: | IGG1-KAPPA 4D5 FAB (HEAVY CHAIN), IGG1-KAPPA 4D5 FAB (LIGHT CHAIN) | Authors: | Eigenbrot, C, Presta, L, Randal, M, Kossiakoff, A.A. | Deposit date: | 1992-10-20 | Release date: | 1993-10-31 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J.Mol.Biol., 229, 1993
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1PG7
 
 | Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab | Descriptor: | humanized antibody D3H44, murine antibody 6A6 Fab fragment | Authors: | Eigenbrot, C, Meng, Y.G, Krishnamurthy, R, Lipari, M.T, Presta, L, Devaux, B, Wong, T, Moran, P, Bullens, S, Kirchhofer, D. | Deposit date: | 2003-05-27 | Release date: | 2003-08-26 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation. J.Mol.Biol., 331, 2003
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1FGV
 
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5KUP
 
 | Bruton's tyrosine kinase (BTK) with pyridazinone compound 9 | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one, GLYCEROL, ... | Authors: | Eigenbrot, C, Yu, C. | Deposit date: | 2016-07-13 | Release date: | 2016-09-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.389 Å) | Cite: | Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations. Acs Chem.Biol., 11, 2016
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2R0L
 
 | Short Form HGFA with Inhibitory Fab75 | Descriptor: | Hepatocyte growth factor activator, antibody heavy chain, Fab portion only, ... | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2007-08-20 | Release date: | 2007-12-25 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2R0K
 
 | Protease domain of HGFA with inhibitor Fab58 | Descriptor: | Hepatocyte growth factor activator, antibody heavy chain of Fab58, Fab portion only, ... | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2007-08-20 | Release date: | 2007-12-25 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104, 2007
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3N85
 
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3NYX
 
 | Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2010-07-15 | Release date: | 2010-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A new regulatory switch in a JAK protein kinase. Proteins, 79, 2011
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3P11
 
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3NZ0
 
 | Non-phosphorylated TYK2 kinase with CMP6 | Descriptor: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Non-receptor tyrosine-protein kinase TYK2 | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2010-07-15 | Release date: | 2010-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A new regulatory switch in a JAK protein kinase. Proteins, 79, 2011
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3P0V
 
 | anti-EGFR/HER3 Fab DL11 alone | Descriptor: | CALCIUM ION, Fab DL11 heavy chain, Fab DL11 light chain | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2010-09-29 | Release date: | 2011-10-19 | Last modified: | 2024-11-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell, 20, 2011
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3P0Y
 
 | anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2010-09-29 | Release date: | 2011-10-26 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell, 20, 2011
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