1JBU | | COAGULATION FACTOR VII ZYMOGEN (EGF2/PROTEASE) IN COMPLEX WITH INHIBITORY EXOSITE PEPTIDE A-183 | | Descriptor: | COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, SULFATE ION, ... | | Authors: | Eigenbrot, C., Kirchhofer, D., Dennis, M.S., Santell, L., Lazarus, R.A., Stamos, J., Ultsch, M.H. | | Deposit date: | 2001-06-06 | | Release date: | 2001-07-11 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
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1AAL | |
3TJN | | HTRA1 CATALYTIC DOMAIN, APO FORM | | Descriptor: | Serine protease HTRA1 | | Authors: | Eigenbrot, C., Ultsch, M. | | Deposit date: | 2011-08-24 | | Release date: | 2012-05-16 | | Last modified: | 2012-06-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
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3TJO | |
3TJQ | | N-DOMAIN OF HTRA1 | | Descriptor: | Serine protease HTRA1, PLATINUM (II) ION, CHLORIDE ION, ... | | Authors: | Eigenbrot, C., Ultsch, M. | | Deposit date: | 2011-08-24 | | Release date: | 2012-05-16 | | Last modified: | 2012-06-27 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
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6RLX | |
1FVC | | X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING | | Descriptor: | IGG1-KAPPA 4D5 FV (LIGHT CHAIN), IGG1-KAPPA 4D5 FV (HEAVY CHAIN) | | Authors: | Eigenbrot, C., Randal, M., Kossiakoff, A.A., Presta, L. | | Deposit date: | 1992-10-20 | | Release date: | 1993-10-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
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1FVD | | X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING | | Descriptor: | IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN) | | Authors: | Eigenbrot, C., Presta, L., Randal, M., Kossiakoff, A.A. | | Deposit date: | 1992-10-20 | | Release date: | 1993-10-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
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1FVE | | X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING | | Descriptor: | IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN) | | Authors: | Eigenbrot, C., Randal, M., Presta, L., Kossiakoff, A.A. | | Deposit date: | 1992-10-20 | | Release date: | 1993-10-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
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1AGQ | | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT | | Descriptor: | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR | | Authors: | Eigenbrot, C., Gerber, N. | | Deposit date: | 1997-03-25 | | Release date: | 1997-06-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.
Nat.Struct.Biol., 4, 1997
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1FGV | |
1ICW | | INTERLEUKIN-8, MUTANT WITH GLU 38 REPLACED BY CYS AND CYS 50 REPLACED BY ALA | | Descriptor: | INTERLEUKIN-8 | | Authors: | Eigenbrot, C., Lowman, H.B., Chee, L., Artis, D.R. | | Deposit date: | 1996-09-18 | | Release date: | 1997-03-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of E38C/C50AIL-8 at 2 A resolution.
Proteins, 27, 1997
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1PG7 | | MURINE 6A6 FAB IN COMPLEX WITH HUMANIZED ANTI-TISSUE FACTOR D3H44 FAB | | Descriptor: | humanized antibody D3H44, murine antibody 6A6 Fab fragment | | Authors: | Eigenbrot, C., Meng, Y.G., Krishnamurthy, R., Lipari, M.T., Presta, L., Devaux, B., Wong, T., Moran, P., Bullens, S., Kirchhofer, D. | | Deposit date: | 2003-05-27 | | Release date: | 2003-08-26 | | Last modified: | 2014-02-05 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.
J.Mol.Biol., 331, 2003
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2FGW | |
3MZW | |
7PTI | |
4EI4 | | JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 20 | | Descriptor: | Tyrosine-protein kinase JAK1, (1R,3R)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8H)-yl)cyclohexanol | | Authors: | Eigenbrot, C., Steffek, M. | | Deposit date: | 2012-04-04 | | Release date: | 2012-07-04 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
J.Med.Chem., 55, 2012
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4HGE | | JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 8 | | Descriptor: | Tyrosine-protein kinase JAK2, N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | | Authors: | Eigenbrot, C., Ultsch, M. | | Deposit date: | 2012-10-08 | | Release date: | 2012-10-24 | | Last modified: | 2012-12-12 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
J.Med.Chem., 55, 2012
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4IVA | | JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE | | Descriptor: | Tyrosine-protein kinase JAK2, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile | | Authors: | Eigenbrot, C., Shia, S. | | Deposit date: | 2013-01-22 | | Release date: | 2013-05-22 | | Last modified: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
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4IVB | | JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXANECARBONITRILE | | Descriptor: | Tyrosine-protein kinase JAK1, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile | | Authors: | Eigenbrot, C., Steffek, M. | | Deposit date: | 2013-01-22 | | Release date: | 2013-05-22 | | Last modified: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
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4IVC | | JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR (TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXYL)ACETONITRILE | | Descriptor: | Tyrosine-protein kinase JAK1, (trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)acetonitrile | | Authors: | Eigenbrot, C., Shia, S. | | Deposit date: | 2013-01-22 | | Release date: | 2013-05-22 | | Last modified: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
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4IVD | | JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 34 | | Descriptor: | Tyrosine-protein kinase JAK1, 3-(trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)propanenitrile | | Authors: | Eigenbrot, C., Steffek, M. | | Deposit date: | 2013-01-22 | | Release date: | 2013-05-22 | | Last modified: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
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4K7P | |
4O3T | | ZYMOGEN HGF-BETA/MET WITH ZYMOGEN ACTIVATOR PEPTIDE ZAP.14 | | Descriptor: | Hepatocyte growth factor, Hepatocyte growth factor receptor, ZAP.14, ... | | Authors: | Eigenbrot, C., Landgraf, K.E., Steffek, M. | | Deposit date: | 2013-12-18 | | Release date: | 2014-06-04 | | Last modified: | 2014-07-02 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Nat.Chem.Biol., 10, 2014
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4O3U | |
