5KUP

Bruton's tyrosine kinase (BTK) with pyridazinone compound 9

Summary for 5KUP

DescriptorTyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total)
Functional Keywordsprotein kinase, inhibitor, non covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q06187
Total number of polymer chains1
Total molecular weight32812.6
Authors
Eigenbrot, C.,Yu, C. (deposition date: 2016-07-13, release date: 2016-09-14, Last modification date: 2016-11-02)
Primary citation
Johnson, A.R.,Kohli, P.B.,Katewa, A.,Gogol, E.,Belmont, L.D.,Choy, R.,Penuel, E.,Burton, L.,Eigenbrot, C.,Yu, C.,Ortwine, D.F.,Bowman, K.,Franke, Y.,Tam, C.,Estevez, A.,Mortara, K.,Wu, J.,Li, H.,Lin, M.,Bergeron, P.,Crawford, J.J.,Young, W.B.
Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.
Acs Chem.Biol., 11:2897-2907, 2016
PubMed: 27571029 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.6b00480
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.389 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.177300.4%4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5kup
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Molmil generated image of 5kup
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Molmil generated image of 5kup
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