3P11

anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region

Summary for 3P11

• Entry DOI: 10.2210/pdb3p11/pdb
• Related: 3P0V 3P0Y
• Descriptor: Fab DL11 heavy chain, Fab DL11 light chain, Receptor tyrosine-protein kinase erbB-3, ... (5 entities in total)
• Functional Keywords: beta-sandwich, antigens her3, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 106133.06

Authors

Eigenbrot, C.,Shia, S. (deposition date: 2010-09-29, release date: 2011-10-26, Last modification date: 2020-07-29)

• Primary citation: Schaefer, G.,Haber, L.,Crocker, L.M.,Shia, S.,Shao, L.,Dowbenko, D.,Totpal, K.,Wong, A.,Lee, C.V.,Stawicki, S.,Clark, R.,Fields, C.,Lewis Phillips, G.D.,Prell, R.A.,Danilenko, D.M.,Franke, Y.,Stephan, J.P.,Hwang, J.,Wu, Y.,Bostrom, J.,Sliwkowski, M.X.,Fuh, G.,Eigenbrot, C.; A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.; Cancer Cell, 20:472-486, 2011; PubMed: 22014573; DOI: 10.1016/j.ccr.2011.09.003

Experimental method

X-RAY DIFFRACTION (3.7 Å)