3P11
anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Fab DL11 heavy chain | polymer | 228 | 24000.7 | 1 | Homo sapiens (human) | ||
| 2 | B (L) | Fab DL11 light chain | polymer | 214 | 23385.9 | 1 | Homo sapiens (human) | ||
| 3 | C (A) | Receptor tyrosine-protein kinase erbB-3 | polymer | 522 | 57879.6 | 1 | UniProt (P21860) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (human) | Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3 |
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 1 - 513 (UniProt: P21860)
| PDB | External Database | Details |
|---|---|---|
| Gly 514 | - | expression tag |
| Asn 515 | - | expression tag |
| Ser 516 | - | expression tag |
| His 517 | - | expression tag |
| His 518 | - | expression tag |
| His 519 | - | expression tag |
| His 520 | - | expression tag |
| His 521 | - | expression tag |
| His 522 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 105266.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 106133.1 |
