Protease domain of HGFA with inhibitor Fab58

Summary for 2R0K

Related1YBW 1YC0 2R0L
DescriptorHepatocyte growth factor activator, antibody light chain of Fab58, antibody heavy chain of Fab58, Fab portion only (3 entities in total)
Functional Keywordsserine protease, antibody, inhibitor, egf-like domain, glycoprotein, hydrolase, kringle, secreted, zymogen, immune system
Biological sourceHomo sapiens (human)
Cellular locationSecreted Q04756
Total number of polymer chains3
Total molecular weight77861.43
Eigenbrot, C.,Shia, S. (deposition date: 2007-08-20, release date: 2007-12-25, Last modification date: 2017-10-25)
Primary citation
Wu, Y.,Eigenbrot, C.,Liang, W.C.,Stawicki, S.,Shia, S.,Fan, B.,Ganesan, R.,Lipari, M.T.,Kirchhofer, D.
Structural insight into distinct mechanisms of protease inhibition by antibodies.
Proc.Natl.Acad.Sci.Usa, 104:19784-19789, 2007
PubMed: 18077410 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0708251104
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.312141.8%7.8%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2r0k
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Molmil generated image of 2r0k
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Molmil generated image of 2r0k
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