Author results

1G2I
  • Download 1g2i
  • View 1g2i
Molmil generated image of 1g2i
CRYSTAL STRUCTURE OF A NOVEL INTRACELLULAR PROTEASE FROM PYROCOCCUS HORIKOSHII AT 2 A RESOLUTION
Descriptor:PROTEASE I, SULFATE ION
Authors:Du, X., Choi, I.-G., Kim, R., Jancarik, J., Kim, S.-H., Berkeley Structural Genomics Center (BSGC)
Deposit date:2000-10-19
Release date:2000-11-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution.
Proc.Natl.Acad.Sci.USA, 97, 2000
1ILW
  • Download 1ilw
  • View 1ilw
Molmil generated image of 1ilw
CRYSTAL STRUCTURE OF PYRAZINAMIDASE/NICOTINAMIDASE OF PYROCOCCUS HORIKOSHII
Descriptor:180 aa long hypothetical Pyrazinamidase/nicotinamidase
Authors:Du, X., Kim, S.-H., Berkeley Structural Genomics Center (BSGC)
Deposit date:2001-05-08
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii.
Biochemistry, 40, 2001
1IM5
  • Download 1im5
  • View 1im5
Molmil generated image of 1im5
CRYSTAL STRUCTURE OF PYRAZINAMIDASE OF PYROCOCCUS HORIKOSHII IN COMPLEX WITH ZINC
Descriptor:180aa long hypothetical Pyrazinamidase/Nicotinamidase, ZINC ION
Authors:Du, X., Kim, S.-H.
Deposit date:2001-05-09
Release date:2001-12-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii.
Biochemistry, 40, 2001
6CZW
  • Download 6czw
  • View 6czw
Molmil generated image of 6czw
CRYSTAL STRUCTURE OF PT1940 BOUND TO HIF2A-B*:ARNT-B* COMPLEX
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, {2-bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol
Authors:Du, X.
Deposit date:2018-04-09
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6D09
  • Download 6d09
  • View 6d09
Molmil generated image of 6d09
CRYSTAL STRUCTURE OF PT2440 BOUND TO HIF2A-B*:ARNT-B* COMPLEX
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-{[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1H-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile
Authors:Du, X.
Deposit date:2018-04-10
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6D0B
  • Download 6d0b
  • View 6d0b
Molmil generated image of 6d0b
CRYSTAL STRUCTURE OF PT1614 BOUND TO HIF2A-B*:ARNT-B* COMPLEX
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-(3-chloro-5-fluorophenyl)-2-nitro-4-[(trifluoromethyl)sulfonyl]aniline
Authors:Du, X.
Deposit date:2018-04-10
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of PT1614 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6D0C
  • Download 6d0c
  • View 6d0c
Molmil generated image of 6d0c
CRYSTAL STRUCTURE OF HIF2A-B*:ARNT-B* COMPLEX
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator
Authors:Du, X.
Deposit date:2018-04-10
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
To Be Published
5ZWX
  • Download 5zwx
  • View 5zwx
Molmil generated image of 5zwx
CRYSTAL STRUCTURE OF RAPHANUS SATIVUS AGDP1 AGD12 IN COMPLEX WITH AN H3K9ME2 PEPTIDE
Descriptor:DUF724 domain-containing protein 6-like, H3(1-15)K9me2 peptide
Authors:Du, X., Du, J.
Deposit date:2018-05-17
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5ZWZ
  • Download 5zwz
  • View 5zwz
Molmil generated image of 5zwz
CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGDP1 AGD34
Descriptor:Agenet domain-containing protein
Authors:Du, X., Du, J.
Deposit date:2018-05-17
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5TBM
  • Download 5tbm
  • View 5tbm
Molmil generated image of 5tbm
CRYSTAL STRUCTURE OF PT2385 BOUND TO HIF2A-B*:ARNT-B* COMPLEX
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile
Authors:Du, X.
Deposit date:2016-09-12
Release date:2016-09-21
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Small-Molecule Antagonist of HIF2 alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Cancer Res., 76, 2016
5UFP
  • Download 5ufp
  • View 5ufp
Molmil generated image of 5ufp
CRYSTAL STRUCTURE OF PT2399 BOUND TO HIF2A-B*:ARNT-B* COMPLEX
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile
Authors:Du, X.
Deposit date:2017-01-05
Release date:2017-01-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:On-target efficacy of a HIF-2 alpha antagonist in preclinical kidney cancer models.
Nature, 539, 2016
4Z0B
  • Download 4z0b
  • View 4z0b
Molmil generated image of 4z0b
CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI-OFLOXACIN ANTIBODY AND EXPLORATION ITS RECEPTOR BINDING SITE
Descriptor:antibody heavy chain, antibody light chain, PHOSPHATE ION
Authors:He, K., Du, X., Sheng, W., Zhou, X., Wang, J., Wang, S.
Deposit date:2015-03-26
Release date:2016-04-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of the Fab Fragment of an Anti-ofloxacin Antibody and Exploration of Its Specific Binding.
J.Agric.Food Chem., 64, 2016
6DXK
  • Download 6dxk
  • View 6dxk
Molmil generated image of 6dxk
GLUCOCORTICOID RECEPTOR IN COMPLEX WITH COMPOUND 11
Descriptor:Glucocorticoid receptor, (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)
Authors:Rew, Y., Du, X., Eksterowicz, J., Zhou, H., Jahchan, N., Zhu, L., Yan, X., Kawai, H., McGee, L.R., Medina, J.C., Huang, T., Chen, C., Zavorotinskaya, T., Sutimantanapi, D., Waszczuk, J., Jackson, E., Huang, E., Ye, Q., Fantin, V.R., Daqing, S.
Deposit date:2018-06-29
Release date:2018-10-03
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
J. Med. Chem., 61, 2018
1SVK
  • Download 1svk
  • View 1svk
Molmil generated image of 1svk
STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO ALF4 AND GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ...
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1SVS
  • Download 1svs
  • View 1svs
Molmil generated image of 1svs
STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO GPPNHP.
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ...
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZTQ
  • Download 1ztq
  • View 1ztq
Molmil generated image of 1ztq
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-033
Descriptor:Collagenase 3, ZINC ION, CALCIUM ION, ...
Authors:Wu, J., Rush III, T.S., Hotchandani, R., Du, X., Geck, M., Collins, E., Xu, Z.B., Skotnicki, J., Levin, J.I., Lovering, F.
Deposit date:2005-05-27
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of potent and selective MMP-13 inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
4JHA
  • Download 4jha
  • View 4jha
Molmil generated image of 4jha
CRYSTAL STRUCTURE OF RSV-NEUTRALIZING HUMAN ANTIBODY D25
Descriptor:D25 antigen-binding fragment heavy chain, D25 light chain
Authors:Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S.
Deposit date:2013-03-04
Release date:2013-05-01
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
4JHW
  • Download 4jhw
  • View 4jhw
Molmil generated image of 4jhw
CRYSTAL STRUCTURE OF RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN STABILIZED IN THE PREFUSION CONFORMATION BY HUMAN ANTIBODY D25
Descriptor:D25 antigen-binding fragment heavy chain, D25 light chain, Fusion glycoprotein F0
Authors:Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S.
Deposit date:2013-03-05
Release date:2013-05-01
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
5Z8L
  • Download 5z8l
  • View 5z8l
Molmil generated image of 5z8l
CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA EBS IN COMPLEX WITH AN H3K27ME3 PEPTIDE
Descriptor:Chromatin remodeling protein EBS, H3K27me3 peptide, ZINC ION
Authors:Yang, Z., Du, J.
Deposit date:2018-01-31
Release date:2018-07-25
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
5Z8N
  • Download 5z8n
  • View 5z8n
Molmil generated image of 5z8n
CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA EBS C-TERMINAL DELETION CONSTRUCT IN COMPLEX WITH AN H3K4ME2 PEPTIDE
Descriptor:Chromatin remodeling protein EBS, H3K4me2 peptide, ZINC ION
Authors:Yang, Z., Du, J.
Deposit date:2018-01-31
Release date:2018-07-25
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
1ZXC
  • Download 1zxc
  • View 1zxc
Molmil generated image of 1zxc
CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF TNF-ALPHA CONVERTING ENZYME (TACE) WITH INHIBITOR
Descriptor:ADAM 17, ZINC ION, (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
Authors:Levin, J.I., Chen, J.M., Laakso, L.M., Du, M., Schmid, J., Xu, W., Cummons, T., Xu, J., Zhang, Y., Jin, G., Cowling, R., Barone, D., Skotnicki, J.S.
Deposit date:2005-06-07
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
Bioorg.Med.Chem.Lett., 15, 2005
5HH7
  • Download 5hh7
  • View 5hh7
Molmil generated image of 5hh7
CRYSTAL STRUCTURE OF ARABIDOPSIS ORC1B BAH-PHD CASSETTE IN COMPLEX WITH UNMODIFIED H3 PEPTIDE
Descriptor:Origin of replication complex subunit 1B, Histone H3 1-15 peptide, ZINC ION
Authors:Li, S., Du, J.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2016-03-16
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette
Structure, 24, 2016
3UNP
  • Download 3unp
  • View 3unp
Molmil generated image of 3unp
STRUCTURE OF HUMAN SUN2 SUN DOMAIN
Descriptor:SUN domain-containing protein 2, ACETYL GROUP
Authors:Zhou, Z.C., Greene, M.I.
Deposit date:2011-11-16
Release date:2011-12-21
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope
J.Biol.Chem., 287, 2012
5ZM5
  • Download 5zm5
  • View 5zm5
Molmil generated image of 5zm5
CRYSTAL STRUCTURE OF HUMAN ORP1-ORD IN COMPLEX WITH CHOLESTEROL AT 2.6 A RESOLUTION
Descriptor:Oxysterol-binding protein-related protein 1, CHOLESTEROL
Authors:Dong, J., Wang, J., Wu, J.W.
Deposit date:2018-04-01
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.
Nat Commun, 10, 2019
5ZM6
  • Download 5zm6
  • View 5zm6
Molmil generated image of 5zm6
CRYSTAL STRUCTURE OF ORP1-ORD IN COMPLEX WITH PI(4,5)P2
Descriptor:Oxysterol-binding protein-related protein 1, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate, ACETATE ION
Authors:Dong, J., Wang, J., Luo, Z., Wu, J.W.
Deposit date:2018-04-01
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.
Nat Commun, 10, 2019
<12>