Author results

5W19
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TRYPTOPHAN INDOLE-LYASE COMPLEX WITH OXINDOLYL-L-ALANINE
分子名称:Tryptophanase, POTASSIUM ION, 1-carboxy-1-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]azaniumyl}-2-[(3R)-2-oxo-2,3-dihydro-1H-indol-3-yl]ethan-1-ide
著者Phillips, R.S., Wood, Z.A.
登録日2017-06-02
公開日2018-06-06
最終更新日2018-12-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism.
Acta Crystallogr D Struct Biol, 74, 2018
5KQV
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1,CR,L2, FNIII-1 AND ALPHACT PEPTIDE IN COMPLEX WITH BOVINE INSULIN AND FAB 83-14 (REVISED STRUCTURE)
分子名称:Insulin, MONOCLONAL ANTIBODY FAB 83-14 - HEAVY CHAIN, MONOCLONAL ANTIBODY FAB 83-14 - LIGHT CHAIN, ...
著者Lawrence, M.C., Smith, B.J., Croll, T.I.
登録日2016-07-06
公開日2017-07-19
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (4.4 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
5IQP
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14-3-3 PROTEIN TAU ISOFORM
分子名称:14-3-3 protein theta, SULFATE ION
著者Xiao, B., Smerdon, S.J., Gamblin, S.J.
登録日2016-03-11
公開日2016-03-23
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
4LVN
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CRYSTAL STRUCTURE OF PFSUB1-PRODOMAIN-NIMP.M7 FAB COMPLEX
分子名称:Subtilisin-like serine protease, NIMP.M7 Fab light chain, NIMP.M7 Fab heavy chain, ...
著者Withers-Martinez, C., Blackman, M.J.
登録日2013-07-26
公開日2014-05-07
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nat Commun, 5, 2014
4LVO
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CRYSTAL STRUCTURE OF PFSUB1-PRODOMAIN-NIMP.M7 FAB COMPLEX WITH ADDED CACL2
分子名称:Subtilisin-like serine protease, NIMP.M7 Fab light chain, NIMP.M7 Fab heavy chain, ...
著者Withers-Martinez, C., Blackman, M.J.
登録日2013-07-26
公開日2014-05-07
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nat Commun, 5, 2014
3W11
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HUMAN INSULIN, ALPHA-CT PEPTIDE(704-719) AND FAB 83-7
分子名称:Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ...
著者Lawrence, M.C., Smith, B.J.
登録日2012-11-06
公開日2013-01-09
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HIGH-AFFINITY INSULIN ANALOGUE [D-PRO-B26]-DTI-NH2, ALPHA-CT PEPTIDE(704-719) AND FAB 83-7
分子名称:Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ...
著者Lawrence, M.C., Smith, B.J., Brzozowsk, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (4.301 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HIGH-AFFINITY INSULIN ANALOGUE [D-PRO-B26]-DTI-NH2, ALPHACT PEPTIDE(693-719) AND FAB 83-7
分子名称:Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ...
著者Lawrence, M.C., Smith, B.J., Brzozowski, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (4.303 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, PHENOL, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3ZZQ
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ENGINEERED 12-SUBUNIT BACILLUS SUBTILIS TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)
分子名称:TRANSCRIPTION ATTENUATION PROTEIN MTRB, TRYPTOPHAN
著者Chen, C., Smits, C., Dodson, G.G., Shevtsov, M.B., Merlino, N., Gollnick, P., Antson, A.A.
登録日2011-09-02
公開日2011-10-12
最終更新日2016-10-19
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献How to Change the Oligomeric State of a Circular Protein Assembly: Switch from 11-Subunit to 12-Subunit Trap Suggests a General Mechanism
Plos One, 6, 2011
3ZZS
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ENGINEERED 12-SUBUNIT BACILLUS STEAROTHERMOPHILUS TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)
分子名称:TRANSCRIPTION ATTENUATION PROTEIN MTRB, TRYPTOPHAN
著者Chen, C., Smits, C., Dodson, G.G., Shevtsov, M.B., Merlino, N., Gollnick, P., Antson, A.A.
登録日2011-09-02
公開日2011-10-12
最終更新日2011-10-26
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献How to Change the Oligomeric State of a Circular Protein Assembly: Switch from 11-Subunit to 12-Subunit Trap Suggests a General Mechanism
Plos One, 6, 2011
3ZZL
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BACILLUS HALODURANS TRP RNA-BINDING ATTENUATION PROTEIN (TRAP): A 12- SUBUNIT ASSEMBLY
分子名称:TRANSCRIPTION ATTENUATION PROTEIN MTRB, TRYPTOPHAN
著者Chen, C., Smits, C., Dodson, G.G., Shevtsov, M.B., Merlino, N., Gollnick, P., Antson, A.A.
登録日2011-09-01
公開日2011-10-12
最終更新日2011-10-26
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献How to Change the Oligomeric State of a Circular Protein Assembly: Switch from 11-Subunit to 12-Subunit Trap Suggests a General Mechanism
Plos One, 6, 2011
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2011-04-26
公開日2012-05-02
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3MJI
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ACTIVATION OF CATALYTIC CYSTEINE WITHOUT A BASE IN A MUTANT PENICILLIN ACYLASE PRECURSOR
分子名称:Penicillin acylase
著者Pathak, M.C., Suresh, C.G., Dodson, G.G., Murshudov, G.N.
登録日2010-04-12
公開日2011-07-20
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Activation of catalytic cysteine without a base in a Mutant Penicillin Acylase Precursor
To be Published
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
登録日2009-11-17
公開日2010-02-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2009-09-10
公開日2010-09-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
2WS0
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN NMEALAB26-INSULIN AT PH 7.5
分子名称:INSULIN A CHAIN, INSULIN B CHAIN
著者Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
登録日2009-09-03
公開日2010-02-09
最終更新日2012-06-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS1
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN NMETYRB26-INSULIN IN MONOMER FORM
分子名称:INSULIN A CHAIN, INSULIN B CHAIN, ACETATE ION
著者Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
登録日2009-09-03
公開日2010-02-09
最終更新日2012-04-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS4
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN PROB26-DTI IN MONOMER FORM
分子名称:INSULIN A CHAIN, INSULIN B CHAIN
著者Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
登録日2009-09-03
公開日2010-02-09
最終更新日2012-04-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS6
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN NMETYRB26-INSULIN IN HEXAMER FORM
分子名称:INSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ...
著者Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
登録日2009-09-03
公開日2010-02-09
最終更新日2012-04-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS7
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN PROB26-DTI
分子名称:INSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ...
著者Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
登録日2009-09-03
公開日2010-02-09
最終更新日2012-06-06
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WRU
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SEMI-SYNTHETIC HIGHLY ACTIVE ANALOGUE OF HUMAN INSULIN NMEALAB26-DTI- NH2
分子名称:INSULIN A CHAIN, INSULIN B CHAIN, ACETATE ION
著者Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
登録日2009-09-02
公開日2010-02-09
最終更新日2013-03-20
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010