6P3S
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6P3R
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7SFV
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7SFW
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7SFU
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5ANY
| Electron cryo-microscopy of chikungunya virus in complex with neutralizing antibody Fab CHK265 | Descriptor: | E1, E2, FAB, ... | Authors: | Fox, J.M, Long, F, Edeling, M.A, Lin, H, Duijl-Richter, M, Fong, R.H, Kahle, K.M, Smit, J.M, Jin, J, Simmons, G, Doranz, B.J, Crowe, J.E, Fremont, D.H, Rossmann, M.G, Diamond, M.S. | Deposit date: | 2015-09-08 | Release date: | 2015-11-25 | Last modified: | 2018-10-03 | Method: | ELECTRON MICROSCOPY (16.9 Å) | Cite: | Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress. Cell(Cambridge,Mass.), 163, 2015
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4UIH
| Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human antibody 2D22 Fab at 37 degree C. The Fab molecules were added to the virus before 37 degree C incubation. | Descriptor: | ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -LIGHT CHAIN, DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C E PROTEIN ECTODOMAIN | Authors: | Fibriansah, G, Ibarra, K.D, Ng, T.-S, Smith, S.A, Tan, J.L, Lim, X.N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe, J.E, Lok, S.-M. | Deposit date: | 2015-03-30 | Release date: | 2015-07-15 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers. Science, 349, 2015
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6BP2
| Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ... | Authors: | King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O. | Deposit date: | 2017-11-21 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.172 Å) | Cite: | The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe, 23, 2018
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5UQY
| Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP1, ... | Authors: | Hashiguchi, T, Fusco, M.L, Hastie, K.M, Bomholdt, Z.A, Lee, J.E, Flyak, A.I, Matsuoka, R, Kohda, D, Yanagi, Y, Hammel, M, Crowe, J.E, Saphire, E.O. | Deposit date: | 2017-02-08 | Release date: | 2017-03-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell, 160, 2015
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5ITB
| Crystal structure of the anti-RSV F Fab 14N4 | Descriptor: | anti-RSV F Fab 14N4 Heavy chain, anti-RSV F Fab 14N4 Light chain | Authors: | Mousa, J.J, Crowe, J.E. | Deposit date: | 2016-03-16 | Release date: | 2016-10-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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5J3D
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5CGY
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5CHN
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4HFW
| Anti Rotavirus Antibody | Descriptor: | 6-26 Fab Heavy chain, 6-26 Fab Light chain, SULFATE ION | Authors: | Spiller, B.W, Aiyegbo, M, Crowe, J.E. | Deposit date: | 2012-10-05 | Release date: | 2013-05-29 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore. Plos One, 8, 2013
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5TPN
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5WEQ
| The crystal structure of a MR78 mutant | Descriptor: | MR78 mutant Fab heavy chain, MR78 mutant light chain | Authors: | Dong, J, Williamson, L.E, Crowe, J.E. | Deposit date: | 2017-07-10 | Release date: | 2018-04-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure, 25, 2017
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6CHX
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6VY4
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6OZ9
| Ebola virus glycoprotein in complex with EBOV-520 Fab | Descriptor: | EBOV-520 Fab heavy chain, EBOV-520 Fab light chain, Envelope glycoprotein, ... | Authors: | Milligan, J.C, Altman, P.X, Hui, S, Hastie, K.M, Gilchuk, P, Crowe, J.E, Saphire, E.O. | Deposit date: | 2019-05-15 | Release date: | 2020-03-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.462 Å) | Cite: | Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization. Immunity, 52, 2020
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6P9J
| crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab | Descriptor: | TRIS(HYDROXYETHYL)AMINOMETHANE, human anti staphylococcus aureus antibody STAU-229 Fab heavy chain, human anti staphylococcus aureus antibody STAU-229 Fab light chain | Authors: | Dong, J, Crowe, J.E. | Deposit date: | 2019-06-10 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis. Mbio, 10, 2019
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6P9I
| crystal structure of human anti staphylococcus aureus antibody STAU-399 Fab | Descriptor: | human anti staphylococcus aureus antibody STAU-399 Fab heavy chain, human anti staphylococcus aureus antibody STAU-399 Fab light chain | Authors: | Dong, J, Crowe, J.E. | Deposit date: | 2019-06-10 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis. Mbio, 10, 2019
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4XNM
| Antibody Influenza H5 Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, H5.3 FAB Heavy Chain, H5.3 FAB Light Chain, ... | Authors: | Winarski, K.L, Spiler, B.W. | Deposit date: | 2015-01-15 | Release date: | 2015-07-15 | Last modified: | 2022-03-30 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites. Proc.Natl.Acad.Sci.USA, 112, 2015
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6WDS
| Enterovirus D68 in complex with human monoclonal antibody EV68-159 | Descriptor: | EV68-159 heavy chain, EV68-159 light chain, viral protein 1, ... | Authors: | Fu, J, Klose, T, Vogt, M.R, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-01 | Release date: | 2020-07-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease. Sci Immunol, 5, 2020
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6WDT
| Enterovirus D68 in complex with human monoclonal antibody EV68-228 | Descriptor: | EV68-228 heavy chain, EV68-228 light chain, viral protein 1, ... | Authors: | Fu, J, Vogt, M.R, Klose, T, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-01 | Release date: | 2020-07-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease. Sci Immunol, 5, 2020
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4M5Z
| Crystal structure of broadly neutralizing antibody 5J8 bound to 2009 pandemic influenza hemagglutinin, HA1 subunit | Descriptor: | Fab 5J8 heavy chain, Fab 5J8 light chain, Hemagglutinin HA1 chain | Authors: | Hong, M, Lee, P.S, Wilson, I.A. | Deposit date: | 2013-08-08 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site. J.Virol., 87, 2013
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