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4Y7N
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BU of 4y7n by Molmil
The Structure Insight into 5-Carboxycytosine Recognition by RNA Polymerase II during Transcription Elongation.
Descriptor: DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Wang, L, Chong, J, Wang, D.
Deposit date:2015-02-15
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
Nature, 523, 2015
4Y52
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BU of 4y52 by Molmil
Crystal structure of 5-Carboxycytosine Recognition by RNA Polymerase II during Transcription Elongation.
Descriptor: DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Wang, L, Chong, J, Wang, D.
Deposit date:2015-02-11
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
Nature, 523, 2015
4X67
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BU of 4x67 by Molmil
Crystal structure of elongating yeast RNA polymerase II stalled at oxidative Cyclopurine DNA lesions.
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Wang, L, Chong, J, Wang, D.
Deposit date:2014-12-07
Release date:2015-02-04
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions.
Proc.Natl.Acad.Sci.USA, 112, 2015
4X6A
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BU of 4x6a by Molmil
Crystal structure of yeast RNA polymerase II encountering oxidative Cyclopurine DNA lesions
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Wang, L, Chong, J, Wang, D.
Deposit date:2014-12-07
Release date:2015-02-04
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.96 Å)
Cite:Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions.
Proc.Natl.Acad.Sci.USA, 112, 2015
7KEF
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BU of 7kef by Molmil
RNA polymerase II elongation complex with unnatural base dTPT3, rNaM in swing state
Descriptor: (1S)-1,4-anhydro-1-(3-methoxynaphthalen-2-yl)-5-O-phosphono-D-ribitol, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Oh, J, Wang, D.
Deposit date:2020-10-10
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.89 Å)
Cite:Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.
Nat.Chem.Biol., 17, 2021
7KED
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BU of 7ked by Molmil
RNA polymerase II elongation complex with unnatural base dTPT3
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Oh, J, Wang, W, Wang, D.
Deposit date:2020-10-10
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.
Nat.Chem.Biol., 17, 2021
7KEE
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BU of 7kee by Molmil
RNA polymerase II elongation complex with unnatural base dTPT3, rNaMTP bound to E-site
Descriptor: (1S)-1,4-anhydro-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-1-(3-methoxynaphthalen-2-yl)-D-ribitol, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Oh, J, Wang, D.
Deposit date:2020-10-10
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.
Nat.Chem.Biol., 17, 2021
8DH4
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BU of 8dh4 by Molmil
T7 RNA polymerase elongation complex with unnatural base dPa-DsTP pair
Descriptor: (7P)-3-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-7-(thiophen-2-yl)-3H-imidazo[4,5-b]pyridine, MAGNESIUM ION, Non-template strand DNA, ...
Authors:Oh, J, Wang, D.
Deposit date:2022-06-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
8DH3
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BU of 8dh3 by Molmil
T7 RNA polymerase elongation complex with unnatural base dPa
Descriptor: Non-template strand DNA, RNA, T7 RNA polymerase, ...
Authors:Oh, J, Wang, D.
Deposit date:2022-06-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
8DH1
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BU of 8dh1 by Molmil
T7 RNA polymerase elongation complex with unnatural base dDs-PaTP pair
Descriptor: 1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-1H-pyrrole-2-carbaldehyde, GLYCEROL, MAGNESIUM ION, ...
Authors:Oh, J, Wang, D.
Deposit date:2022-06-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
8DH0
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BU of 8dh0 by Molmil
T7 RNA polymerase elongation complex with unnatural base dDs
Descriptor: GLYCEROL, Non-template strand DNA, RNA, ...
Authors:Oh, J, Wang, D.
Deposit date:2022-06-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
8DH5
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BU of 8dh5 by Molmil
T7 RNA polymerase elongation complex with unnatural base dPa-ATP mismatch
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-template strand DNA, ...
Authors:Oh, J, Wang, D.
Deposit date:2022-06-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
8DH2
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BU of 8dh2 by Molmil
T7 RNA polymerase elongation complex with unnatural base dDs-ATP mismatch
Descriptor: GLYCEROL, MAGNESIUM ION, Non-template strand DNA, ...
Authors:Oh, J, Wang, D.
Deposit date:2022-06-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
7RIX
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BU of 7rix by Molmil
RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2
Descriptor: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Oh, J, Dervan, P.B, Wang, D.
Deposit date:2021-07-20
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RIW
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BU of 7riw by Molmil
RNA polymerase II elongation complex scaffold 2, without polyamide
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Oh, J, Dervan, P.B, Wang, D.
Deposit date:2021-07-20
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RIL
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BU of 7ril by Molmil
Crystal structure of hairpin polyamide Py-Im 1 bound to 5' CCTGACCAGG
Descriptor: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, ACETATE ION, non-template DNA, ...
Authors:Oh, J, Dervan, P.B, Wang, D.
Deposit date:2021-07-20
Release date:2022-01-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RIM
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BU of 7rim by Molmil
RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1
Descriptor: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Oh, J, Dervan, P.B, Wang, D.
Deposit date:2021-07-20
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RIY
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BU of 7riy by Molmil
RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2 soaked with UTP
Descriptor: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Oh, J, Dervan, P.B, Wang, D.
Deposit date:2021-07-20
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RIP
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BU of 7rip by Molmil
RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1 soaked with CTP
Descriptor: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Oh, J, Dervan, P.B, Wang, D.
Deposit date:2021-07-20
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RIQ
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BU of 7riq by Molmil
RNA polymerase II elongation complex scaffold 1 without polyamide
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Oh, J, Dervan, P.B, Wang, D.
Deposit date:2021-07-20
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
5VVR
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BU of 5vvr by Molmil
Ternary complex of RNA Pol II, transcription scaffold and Rad26
Descriptor: DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ...
Authors:Lahiri, I, Leschziner, A.E.
Deposit date:2017-05-19
Release date:2017-11-22
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.
Nature, 551, 2017
5VVS
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BU of 5vvs by Molmil
RNA pol II elongation complex
Descriptor: DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Lahiri, I, Leschziner, A.E.
Deposit date:2017-05-20
Release date:2017-11-22
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.
Nature, 551, 2017
8SY5
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BU of 8sy5 by Molmil
E. coli DNA-directed RNA polymerase transcription elongation complex bound the unnatural dS-BTP base pair in the active site
Descriptor: 2-oxo-2-hydroadenosine 5'-(tetrahydrogen triphosphate), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Shan, Z, Lyumkis, D, Oh, J, Wang, D.
Deposit date:2023-05-24
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase.
Nat Commun, 14, 2023
8SY6
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BU of 8sy6 by Molmil
E. coli DNA-directed RNA polymerase transcription elongation complex bound the unnatural dB-UTP base pair in the active site
Descriptor: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Shan, Z, Lyumkis, D, Oh, J, Wang, D.
Deposit date:2023-05-24
Release date:2023-12-27
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase.
Nat Commun, 14, 2023
8SY7
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BU of 8sy7 by Molmil
E. coli DNA-directed RNA polymerase transcription elongation complex bound the unnatural dB-STP base pair in the active site
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Shan, Z, Lyumkis, D, Oh, J, Wang, D.
Deposit date:2023-05-24
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase.
Nat Commun, 14, 2023

 

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