7RIL
Crystal structure of hairpin polyamide Py-Im 1 bound to 5' CCTGACCAGG
Summary for 7RIL
Entry DOI | 10.2210/pdb7ril/pdb |
Descriptor | non-template DNA, template DNA, 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, ... (5 entities in total) |
Functional Keywords | polyamide, small molecule, dna binding molecule, anticancer agent, dna |
Biological source | synthetic construct More |
Total number of polymer chains | 2 |
Total formula weight | 7508.47 |
Authors | Oh, J.,Dervan, P.B.,Wang, D. (deposition date: 2021-07-20, release date: 2022-01-12, Last modification date: 2024-04-03) |
Primary citation | Oh, J.,Jia, T.,Xu, J.,Chong, J.,Dervan, P.B.,Wang, D. RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed: 35022237DOI: 10.1073/pnas.2114065119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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