7RIL

Crystal structure of hairpin polyamide Py-Im 1 bound to 5' CCTGACCAGG

Summary for 7RIL

• Entry DOI: 10.2210/pdb7ril/pdb
• Descriptor: non-template DNA, template DNA, 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, ... (5 entities in total)
• Functional Keywords: polyamide, small molecule, dna binding molecule, anticancer agent, dna
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 7508.47

Authors

Oh, J.,Dervan, P.B.,Wang, D. (deposition date: 2021-07-20, release date: 2022-01-12, Last modification date: 2024-04-03)

• Primary citation: Oh, J.,Jia, T.,Xu, J.,Chong, J.,Dervan, P.B.,Wang, D.; RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.; Proc.Natl.Acad.Sci.USA, 119:-, 2022; PubMed: 35022237; DOI: 10.1073/pnas.2114065119

Experimental method

X-RAY DIFFRACTION (1.8 Å)