Crystal structure of elongating yeast RNA polymerase II stalled at oxidative Cyclopurine DNA lesions.

Summary for 4X67

DescriptorDNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... (13 entities in total)
Functional Keywordspol ii elongation complex oxidative cyclopurine dna lesions, transcription-dna complex, transcription/dna
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Cellular locationNucleus P04050 P08518 P16370 P20434 P20436 P38902
Cytoplasm  P20435
Nucleus, nucleolus  P27999 P22139 P40422
Total number of polymer chains12
Total molecular weight481979.81
Wang, L.,Chong, J.,Wang, D. (deposition date: 2014-12-07, release date: 2015-02-04, Last modification date: 2017-10-04)
Primary citation
Walmacq, C.,Wang, L.,Chong, J.,Scibelli, K.,Lubkowska, L.,Gnatt, A.,Brooks, P.J.,Wang, D.,Kashlev, M.
Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions.
Proc.Natl.Acad.Sci.USA, 112:E410-E419, 2015
PubMed: 25605892 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1415186112
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.281197.2%16.7%1.0%0.32MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution