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2PQM
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CRYSTAL STRUCTURE OF CYSTEINE SYNTHASE (OASS) FROM ENTAMOEBA HISTOLYTICA AT 1.86 A RESOLUTION
Descriptor:Cysteine synthase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Chinthalapudi, K., Alam, N., Gourinath, S.
Deposit date:2007-05-02
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of native O-acetyl-serine sulfhydrylase from Entamoeba histolytica and its complex with cysteine: structural evidence for cysteine binding and lack of interactions with serine acetyl transferase.
Proteins, 72, 2008
2XEL
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MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY
Descriptor:MYOSIN-2 HEAVY CHAIN, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Chinthalapudi, K., Taft, M.H., Martin, R., Hartmann, F.K., Heissler, S.M., Tsiavaliaris, G., Gutzeit, H.O., Knoelker, H.J., Coluccio, L.M., Fedorov, R., Manstein, D.J.
Deposit date:2010-05-16
Release date:2011-06-15
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J.Biol.Chem., 286, 2011
4AE3
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CRYSTAL STRUCTURE OF AMMOSAMIDE 272:MYOSIN-2 MOTOR DOMAIN COMPLEX
Descriptor:MYOSIN-2 HEAVY CHAIN, ADP ORTHOVANADATE, MAGNESIUM ION, ...
Authors:Chinthalapudi, K., Heissler, S.M., Fenical, W., Manstein, D.J.
Deposit date:2012-01-05
Release date:2013-01-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Ammosamide Mediated Myosin Motor Activity Inhibition
To be Published
4PR9
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HUMAN VINCULIN (RESIDUES 891-1066) IN COMPLEX WITH PIP
Descriptor:Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, GLYCEROL
Authors:Chinthalapudi, K., Rangarajan, E.S., Patil, D., Izard, T.
Deposit date:2014-03-05
Release date:2014-12-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Mechanism and function of lipid-directed oligomerization of vinculin
To be Published
5I4E
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CRYSTAL STRUCTURE OF HUMAN NONMUSCLE MYOSIN 2C MOTOR DOMAIN
Descriptor:Myosin-14,Alpha-actinin A, ADP ORTHOVANADATE, MAGNESIUM ION
Authors:Chinthalapudi, K., Heissler, S.M., Preller, M., Sellers, J.R., Manstein, D.J.
Deposit date:2016-02-11
Release date:2017-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Allosteric Regulation of Myosin Function: Insights from the Crystal Structure of the Human Nonmuscle Myosin-2C Motor Domain
To be published
5L0C
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HUMAN METAVINCULIN (RESIDUES 959-1134) IN COMPLEX WITH PIP2
Descriptor:Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0D
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HUMAN METAVINCULIN(RESIDUES 959-1130) IN COMPLEX WITH PIP2
Descriptor:Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0F
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HUMAN METAVINCULIN QUADRUPLE MUTANT (RESIDUES 959-1134)
Descriptor:Vinculin, GLYCEROL
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0G
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HUMAN METAVINCULIN MVT Q971R, R975D, T978R MUTANT (RESIDUES 959-1134) IN COMPLEX WITH PIP2
Descriptor:Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0H
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HUMAN METAVINCULIN MVT CARDIOMYOPATHY-ASSOCIATED MUTANT R975W (RESIDUES 959-1134) IN COMPLEX WITH PIP2
Descriptor:Vinculin, DI(HYDROXYETHYL)ETHER, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ...
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0I
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HUMAN METAVINCULIN MVT R975W CARDIOMYOPATHY-ASSOCIATED MUTANT (RESIDUES 959-1134)
Descriptor:Vinculin, GLYCEROL, SODIUM ION
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0J
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HUMAN VINCULIN R903Q, D907R, R910T MUTANT(RESIDUES 891-1066)
Descriptor:Vinculin
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (4 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
6CDS
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HUMAN NEUROFIBROMIN 2/MERLIN/SCHWANNOMIN RESIDUES 1-339 IN COMPLEX WITH PIP2
Descriptor:Merlin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION, ...
Authors:Chinthalapudi, K., Sharff, A.J., Bricogne, G., Izard, T.
Deposit date:2018-02-09
Release date:2018-07-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9, 2018
6MFS
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MOUSE TALIN1 RESIDUES 1-138 FUSED TO RESIDUES 169-400 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2)
Descriptor:Talin-1 fusion, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION
Authors:Izard, T., Chinthalapudi, K., Rangarajan, E.S.
Deposit date:2018-09-12
Release date:2018-09-26
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2XO8
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CRYSTAL STRUCTURE OF MYOSIN-2 IN COMPLEX WITH TRIBROMODICHLOROPSEUDILIN
Descriptor:MYOSIN-2 HEAVY CHAIN, 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, ...
Authors:Preller, M., Chinthalapudi, K., Martin, R., Knoelker, H.J., Manstein, D.J.
Deposit date:2010-08-10
Release date:2011-05-25
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
J.Med.Chem., 54, 2011
3BM5
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CRYSTAL STRUCTURE OF O-ACETYL-SERINE SULFHYDRYLASE FROM ENTAMOEBA HISTOLYTICA IN COMPLEX WITH CYSTEINE
Descriptor:Cysteine synthase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Krishna, C., Kumar, M., Kumar, S., Gourinath, S.
Deposit date:2007-12-12
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of native O-acetyl-serine sulfhydrylase from Entamoeba histolytica and its complex with cysteine: structural evidence for cysteine binding and lack of interactions with serine acetyl transferase.
Proteins, 72, 2008
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