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6HMI
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BU of 6hmi by Molmil
Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7
Descriptor: RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Campagne, S, Allain, F.H.
Deposit date:2018-09-12
Release date:2019-08-14
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Structural basis of a small molecule targeting RNA for a specific splicing correction.
Nat.Chem.Biol., 15, 2019
2KO0
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BU of 2ko0 by Molmil
Solution structure of the THAP zinc finger of THAP1 in complex with its DNA target
Descriptor: RRM1, THAP domain-containing protein 1, ZINC ION
Authors:Campagne, S, Gervais, V, Saurel, O, Milon, A.
Deposit date:2009-09-08
Release date:2010-01-19
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structural determinants of specific DNA-recognition by the THAP zinc finger
Nucleic Acids Res., 2010
6HMO
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BU of 6hmo by Molmil
Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier
Descriptor: 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Campagne, S, Allain, F.H.
Deposit date:2018-09-12
Release date:2019-08-14
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural basis of a small molecule targeting RNA for a specific splicing correction.
Nat.Chem.Biol., 15, 2019
5IEJ
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BU of 5iej by Molmil
Solution structure of the BeF3-activated conformation of SdrG from Pseudomonas melonis Fr1
Descriptor: SdrG
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2016-02-25
Release date:2016-07-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response.
Structure, 24, 2016
5IEB
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BU of 5ieb by Molmil
Solution structure of SdrG from Sphingomonas melonis Fr1
Descriptor: Sensory transduction regulatory protein
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2016-02-25
Release date:2016-07-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response.
Structure, 24, 2016
7ZAP
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BU of 7zap by Molmil
Solution structure of RBM39 RRM1 bound to U1 snRNA stem loop 3
Descriptor: RNA-binding protein 39, U1 snRNA SL3
Authors:Campagne, S, Allain, F.H.
Deposit date:2022-03-22
Release date:2023-03-29
Last modified:2023-09-20
Method:SOLUTION NMR
Cite:Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.
Nat Commun, 14, 2023
7Q33
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BU of 7q33 by Molmil
Solution structure of RBM39 RRM2 bound to 5'-AGCUUUG-3
Descriptor: RNA (5'-R(*AP*GP*CP*UP*UP*UP*G)-3'), RNA-binding protein 39
Authors:Campagne, S, Allain, F.H.
Deposit date:2021-10-26
Release date:2023-02-08
Last modified:2023-09-20
Method:SOLUTION NMR
Cite:Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.
Nat Commun, 14, 2023
7AEP
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BU of 7aep by Molmil
Solution structure of U1-A RRM2 (190-282)
Descriptor: U1 small nuclear ribonucleoprotein A
Authors:Campagne, S, Allain, F.H.
Deposit date:2020-09-18
Release date:2021-02-03
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands.
Nucleic Acids Res., 49, 2021
4LUP
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BU of 4lup by Molmil
Crystal structure of the complex formed by region of E. coli sigmaE bound to its -10 element non template strand
Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor, region 2 of sigmaE of E. coli
Authors:Campagne, S, Marsh, M.E, Vorholt, J.A.V, Allain, F.H.-T, Capitani, G.
Deposit date:2013-07-25
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis for -10 promoter element melting by environmentally induced sigma factors.
Nat.Struct.Mol.Biol., 21, 2014
2LFW
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BU of 2lfw by Molmil
NMR structure of the PhyRSL-NepR complex from Sphingomonas sp. Fr1
Descriptor: NepR anti sigma factor, PhyR sigma-like domain
Authors:Campagne, S, Damberger, F.F, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2011-07-18
Release date:2012-04-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural basis for sigma factor mimicry in the general stress response of Alphaproteobacteria.
Proc.Natl.Acad.Sci.USA, 109, 2012
2MAO
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BU of 2mao by Molmil
NMR structure of region 2 of E. coli sigmaE
Descriptor: RNA polymerase sigma factor
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2013-07-16
Release date:2014-02-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural basis for -10 promoter element melting by environmentally induced sigma factors.
Nat.Struct.Mol.Biol., 21, 2014
2MAP
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BU of 2map by Molmil
Solution structure of the complex formed by the region 2 of E. coli sigmaE and its cognate -10 promoter element non template strand TGTCAAA.
Descriptor: DNA, RNA polymerase sigma factor
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2013-07-16
Release date:2014-02-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural basis for -10 promoter element melting by environmentally induced sigma factors.
Nat.Struct.Mol.Biol., 21, 2014
2L1G
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BU of 2l1g by Molmil
RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target
Descriptor: DNA (5'-D(*GP*CP*TP*TP*GP*TP*GP*TP*GP*GP*GP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*TP*GP*CP*CP*CP*AP*CP*AP*CP*AP*AP*GP*C)-3'), THAP domain-containing protein 1, ...
Authors:Campagne, S, Gervais, V, Saurel, O, Milon, A.
Deposit date:2010-07-28
Release date:2010-09-08
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target
To be published
2JOS
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BU of 2jos by Molmil
Solution structure of piscidin in presence of DPC micelles
Descriptor: Moronecidin
Authors:Campagna, S, Saint, N, Molle, G, Aumelas, A.
Deposit date:2007-03-21
Release date:2007-04-03
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Structure and mechanism of action of the antimicrobial peptide piscidin
Biochemistry, 46, 2007
5OR5
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BU of 5or5 by Molmil
NMR structure of the complex formed by an engineered region 2 of sigmaE in complex with GTAAAA
Descriptor: DNA (5'-D(*GP*TP*AP*AP*AP*A)-3'), ECF RNA polymerase sigma-E factor,ECF RNA polymerase sigma factor SigW,ECF RNA polymerase sigma-E factor
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.
Deposit date:2017-08-15
Release date:2018-06-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Engineered promoter selectivity of an ECF sigma factor
Not published
6SNJ
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BU of 6snj by Molmil
Solution structure of the FUS/TLS RNA recognition motif in complex with U1 snRNA stem loop III
Descriptor: RNA-binding protein FUS, U1 snRNA stem loop III, RNA (28-MER)
Authors:Campagne, S, Allain, F.H.
Deposit date:2019-08-26
Release date:2020-10-28
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Nat Commun, 11, 2020
2NB9
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BU of 2nb9 by Molmil
Solution structure of ZitP zinc finger
Descriptor: Uncharacterized protein, ZINC ION
Authors:Campagne, S, Berge, M, Viollier, P.H, Allain, F.H.-T.
Deposit date:2016-02-01
Release date:2016-12-14
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria.
Elife, 5, 2016
5OR0
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BU of 5or0 by Molmil
NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA
Descriptor: RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Campagne, S, Clery, A, Allain, F.H.
Deposit date:2017-08-14
Release date:2017-08-30
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.
Nat Commun, 8, 2017
3BEW
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BU of 3bew by Molmil
10mer Crystal Structure of chicken MHC class I haplotype B21
Descriptor: 10-mer from Tubulin beta-6 chain, Beta-2-microglobulin, Major histocompatibility complex class I glycoprotein haplotype B21
Authors:Koch, M, Camp, S, Collen, T, Avila, D, Salomonsen, J, Wallny, H.J, van Hateren, A, Hunt, L, Jacob, J.P, Johnston, F, Marston, D.A, Shaw, I, Dunbar, P.R, Cerundolo, V, Jones, E.Y, Kaufman, J.
Deposit date:2007-11-20
Release date:2008-01-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of an MHC class I molecule from b21 chickens illustrate promiscuous Peptide binding
Immunity, 27, 2007
8CF2
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BU of 8cf2 by Molmil
Solution structure of the RNA helix formed by the 5'-end of U1 snRNA and an A-1 bulged 5'-splice site in complex with SMN-CY
Descriptor: 4-[(3~{S})-3-ethylpiperazin-1-yl]-2-fluoranyl-~{N}-(2-methylimidazo[1,2-a]pyrazin-6-yl)benzamide, RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Marquevielle, J, Campagne, S.
Deposit date:2023-02-02
Release date:2024-02-21
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 52, 2024
6EZ6
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BU of 6ez6 by Molmil
PI3 kinase delta in complex with Methyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate
Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, methyl 2-methoxy-5-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazol-2-yl]-2~{H}-indazol-6-yl]pyridine-3-carboxylate
Authors:Convery, M.A, Campos, S, Dalton, S.E.
Deposit date:2017-11-14
Release date:2017-12-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition.
J. Am. Chem. Soc., 140, 2018
6EYZ
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BU of 6eyz by Molmil
PI3 kinase delta in complex with 4-Fluorophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate
Descriptor: 2-methoxy-5-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazol-2-yl]-2~{H}-indazol-6-yl]pyridine-3-carboxylic acid, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Authors:Convery, M.A, Campos, S, Dalton, S.E.
Deposit date:2017-11-13
Release date:2017-12-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition.
J. Am. Chem. Soc., 140, 2018
8R8P
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BU of 8r8p by Molmil
Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition
Descriptor: 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-6-(4-methylpiperazin-1-yl)quinazoline, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Campagne, S.
Deposit date:2023-11-29
Release date:2024-03-06
Last modified:2024-05-22
Method:SOLID-STATE NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 52, 2024
8R62
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BU of 8r62 by Molmil
Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition
Descriptor: 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-1~{H}-pyrido[1,2-a]pyrimidin-4-one, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Campagne, S.
Deposit date:2023-11-20
Release date:2024-03-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 52, 2024
8R63
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BU of 8r63 by Molmil
Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition
Descriptor: 5-(1~{H}-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridazin-3-yl]phenol, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Campagne, S.
Deposit date:2023-11-20
Release date:2024-03-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 52, 2024

 

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