5OR0
NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA
Summary for 5OR0
Entry DOI | 10.2210/pdb5or0/pdb |
NMR Information | BMRB: 34171 |
Descriptor | RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') (2 entities in total) |
Functional Keywords | 5'-splice site, smn2, small muscular atrophy, rna |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 6975.24 |
Authors | Campagne, S.,Clery, A.,Allain, F.H. (deposition date: 2017-08-14, release date: 2017-08-30, Last modification date: 2024-06-19) |
Primary citation | Sivaramakrishnan, M.,McCarthy, K.D.,Campagne, S.,Huber, S.,Meier, S.,Augustin, A.,Heckel, T.,Meistermann, H.,Hug, M.N.,Birrer, P.,Moursy, A.,Khawaja, S.,Schmucki, R.,Berntenis, N.,Giroud, N.,Golling, S.,Tzouros, M.,Banfai, B.,Duran-Pacheco, G.,Lamerz, J.,Hsiu Liu, Y.,Luebbers, T.,Ratni, H.,Ebeling, M.,Clery, A.,Paushkin, S.,Krainer, A.R.,Allain, F.H.,Metzger, F. Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers. Nat Commun, 8:1476-1476, 2017 Cited by PubMed: 29133793DOI: 10.1038/s41467-017-01559-4 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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