6EYZ

PI3 kinase delta in complex with 4-Fluorophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate

Summary for 6EYZ

Entry DOI	10.2210/pdb6eyz/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 2-methoxy-5-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazol-2-yl]-2~{H}-indazol-6-yl]pyridine-3-carboxylic acid (3 entities in total)
Functional Keywords	covalent inhibitor, kinase, drug discovery, complex, transferase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	121327.88
Authors	Convery, M.A.,Campos, S.,Dalton, S.E. (deposition date: 2017-11-13, release date: 2017-12-20, Last modification date: 2018-01-31)
Primary citation	Dalton, S.E.,Dittus, L.,Thomas, D.A.,Convery, M.A.,Nunes, J.,Bush, J.T.,Evans, J.P.,Werner, T.,Bantscheff, M.,Murphy, J.A.,Campos, S. Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition. J. Am. Chem. Soc., 140:932-939, 2018 Cited by PubMed: 29232121 DOI: 10.1021/jacs.7b08979 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation