6EYZ
PI3 kinase delta in complex with 4-Fluorophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 1051 | 120851.4 | 1 | UniProt (Q3UDT3) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) UniProt (by SIFTS) (O35904) | Mus musculus (Mouse) | |
| 2 | B (A) | 2-methoxy-5-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazol-2-yl]-2~{H}-indazol-6-yl]pyridine-3-carboxylic acid | non-polymer | 476.5 | 1 | Chemie (C5W) | |||
| 3 | C (A) | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence modifications
A: -6 - 1044 (UniProt: Q3UDT3)
| PDB | External Database | Details |
|---|---|---|
| Glu 99 | - | insertion |
| Asn 100 | - | insertion |
| Leu 101 | - | insertion |
| Tyr 102 | - | insertion |
| Phe 103 | - | insertion |
| Gln 104 | - | insertion |
| Gly 105 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 120851.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 476.5 | |
| All* | Total formula weight | 121327.9 |
