6HMI

Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7

Summary for 6HMI

• Entry DOI: 10.2210/pdb6hmi/pdb
• NMR Information: BMRB: 34311
• Descriptor: RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') (2 entities in total)
• Functional Keywords: weak 5'-splice site, u1 snrna, spinal muscular atrophy, bulge nucleotide, rna
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 6975.24

Authors

Campagne, S.,Allain, F.H. (deposition date: 2018-09-12, release date: 2019-08-14, Last modification date: 2023-06-14)

• Primary citation: Campagne, S.,Boigner, S.,Rudisser, S.,Moursy, A.,Gillioz, L.,Knorlein, A.,Hall, J.,Ratni, H.,Clery, A.,Allain, F.H.; Structural basis of a small molecule targeting RNA for a specific splicing correction.; Nat.Chem.Biol., 15:1191-1198, 2019; PubMed: 31636429; DOI: 10.1038/s41589-019-0384-5

Experimental method

SOLUTION NMR