8CF2

Solution structure of the RNA helix formed by the 5'-end of U1 snRNA and an A-1 bulged 5'-splice site in complex with SMN-CY

Summary for 8CF2

• Entry DOI: 10.2210/pdb8cf2/pdb
• NMR Information: BMRB: 34784
• Descriptor: RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 4-[(3~{S})-3-ethylpiperazin-1-yl]-2-fluoranyl-~{N}-(2-methylimidazo[1,2-a]pyrazin-6-yl)benzamide (3 entities in total)
• Functional Keywords: splicing correction, molecular glue, u1 snrnp, bulged 5'-splice site, splicing
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 7357.67

Authors

Malard, F.,Marquevielle, J.,Campagne, S. (deposition date: 2023-02-02, release date: 2024-02-21, Last modification date: 2024-04-10)

• Primary citation: Malard, F.,Wolter, A.C.,Marquevielle, J.,Morvan, E.,Ecoutin, A.,Rudisser, S.H.,Allain, F.H.T.,Campagne, S.; The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.; Nucleic Acids Res., 2024; PubMed: 38554107; DOI: 10.1093/nar/gkae201

Experimental method

SOLUTION NMR