8R8P

Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition

Summary for 8R8P

• Entry DOI: 10.2210/pdb8r8p/pdb
• NMR Information: BMRB: 34885
• Descriptor: RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-6-(4-methylpiperazin-1-yl)quinazoline (3 entities in total)
• Functional Keywords: specific splicing correction, molecular glue, small molecule splicing modifier, u1 snrnp, 5'-splice site recognition, splicing
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 7351.67

Authors

Malard, F.,Campagne, S. (deposition date: 2023-11-29, release date: 2024-03-06, Last modification date: 2024-05-22)

• Primary citation: Malard, F.,Wolter, A.C.,Marquevielle, J.,Morvan, E.,Ecoutin, A.,Rudisser, S.H.,Allain, F.H.T.,Campagne, S.; The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.; Nucleic Acids Res., 52:4124-4136, 2024; PubMed: 38554107; DOI: 10.1093/nar/gkae201

Experimental method

SOLID-STATE NMR