Author results

1B92
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MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor:PROTEIN (INTEGRASE), CACODYLATE ION, SULFATE ION
Authors:Greenwald, J., Le, V., Butler, S.L., Bushman, F.D., Choe, S.
Deposit date:1999-02-19
Release date:1999-07-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
1B9D
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MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor:PROTEIN (INTEGRASE), CACODYLATE ION, SULFATE ION
Authors:Greenwald, J., Le, V., Butler, S.L., Bushman, F.D., Choe, S.
Deposit date:1999-02-11
Release date:1999-07-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
1B9F
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MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor:PROTEIN (INTEGRASE), CACODYLATE ION, SULFATE ION
Authors:Greenwald, J., Le, V., Butler, S.L., Bushman, F.D., Choe, S.
Deposit date:1999-02-11
Release date:1999-07-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
1C0M
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CRYSTAL STRUCTURE OF RSV TWO-DOMAIN INTEGRASE
Descriptor:PROTEIN (INTEGRASE)
Authors:Yang, Z.-N., Mueser, T.C., Bushman, F.D., Hyde, C.C.
Deposit date:1999-07-16
Release date:2000-03-01
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase.
J.Mol.Biol., 296, 2000
1C1A
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CRYSTAL STRUCTURE OF RSV TWO-DOMAIN INTEGRASE
Descriptor:RSV INTEGRASE
Authors:Yang, Z.-N., Mueser, T.C., Bushman, F.D., Hyde, C.C.
Deposit date:1999-07-21
Release date:2000-03-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase.
J.Mol.Biol., 296, 2000
1HYV
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HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM
Descriptor:INTEGRASE, SULFATE ION, CHLORIDE ION, ...
Authors:Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F.D., Siegel, J.S., Choe, S.
Deposit date:2001-01-22
Release date:2001-04-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
Acta Crystallogr.,Sect.D, 57, 2001
1HYZ
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HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM.
Descriptor:INTEGRASE, SULFATE ION, CHLORIDE ION, ...
Authors:Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F.D., Siegel, J.S., Choe, S.
Deposit date:2001-01-22
Release date:2001-04-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
Acta Crystallogr.,Sect.D, 57, 2001
2H7F
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STRUCTURE OF VARIOLA TOPOISOMERASE COVALENTLY BOUND TO DNA
Descriptor:5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', DNA topoisomerase 1
Authors:Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Deposit date:2006-06-02
Release date:2006-08-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for specificity in the poxvirus topoisomerase.
Mol.Cell, 23, 2006
2H7G
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STRUCTURE OF VARIOLA TOPOISOMERASE NON-COVALENTLY BOUND TO DNA
Descriptor:5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', DNA topoisomerase 1
Authors:Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Deposit date:2006-06-02
Release date:2006-08-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specificity in the poxvirus topoisomerase.
Mol.Cell, 23, 2006
3IGC
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SMALLPOX VIRUS TOPOISOMERASE-DNA TRANSITION STATE
Descriptor:DNA topoisomerase 1, 5'-D(*GP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', 5'-D(*AP*TP*TP*CP*C)-3', ...
Authors:Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Deposit date:2009-07-27
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State Mimic.
Structure, 18, 2010
4OJR
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CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC DOMAIN WITH GSK1264
Descriptor:HIV-1 Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, CACODYLATE ION, ...
Authors:Gupta, K., Brady, T., Dyer, B., Hwang, Y., Male, F., Nolte, R.T., Wang, L., Velthuisen, E., Jeffrey, J., Van Duyne, G., Bushman, F.D.
Deposit date:2014-01-21
Release date:2014-06-11
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS.
J.Biol.Chem., 289, 2014
5HOT
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STRUCTURAL BASIS FOR INHIBITOR-INDUCED AGGREGATION OF HIV-1 INTEGRASE
Descriptor:Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid
Authors:Gupta, K., Turkki, V., Sherrill-Mix, S., Hwang, Y., Eilers, G., Taylor, L., McDanal, C., Wang, P., Temelkoff, D., Nolte, R., Velthuisen, E., Jeffrey, J., Van Duyne, G.D., Bushman, F.D.
Deposit date:2016-01-19
Release date:2016-12-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5E6F
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CANARYPOX VIRUS RESOLVASE
Descriptor:CNPV261 Holliday junction resolvase protein, MAGNESIUM ION, D(-)-TARTARIC ACID
Authors:Li, H., Hwang, Y., Perry, K., Bushman, F.D., Van Duyne, G.D.
Deposit date:2015-10-09
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and Metal Binding Properties of a Poxvirus Resolvase.
J.Biol.Chem., 291, 2016
2M9U
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SOLUTION NMR STRUCTURE OF THE C-TERMINAL DOMAIN (CTD) OF MOLONEY MURINE LEUKEMIA VIRUS INTEGRASE, NORTHEAST STRUCTURAL GENOMICS TARGET OR41A
Descriptor:Integrase p46
Authors:Aiyer, S., Rossi, P., Schneider, W.M., Chander, A., Roth, M.J., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-06-19
Release date:2013-12-18
Last modified:2014-06-04
Method:SOLUTION NMR
Cite:Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.
Nucleic Acids Res., 42, 2014
4O0J
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HIV-1 INTEGRASE CATALYTIC CORE DOMAIN COMPLEXED WITH ALLOSTERIC INHIBITOR (2S)-TERT-BUTOXY[4-(4-CHLOROPHENYL)-6-(3,4-DIMETHYLPHENYL)-2,5-DIMETHYLPYRIDIN-3-YL]ETHANOIC ACID
Descriptor:Integrase, (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid, SULFATE ION
Authors:Feng, L., Kvaratskhelia, M.
Deposit date:2013-12-13
Release date:2014-07-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase.
Plos Pathog., 10, 2014
4O55
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HIV-1 INTEGRASE CATALYTIC CORE DOMAIN COMPLEXED WITH ALLOSTERIC INHIBITOR (2S)-TERT-BUTOXY[6-(5-CHLORO-1H-BENZIMIDAZOL-2-YL)-2,5-DIMETHYL-4-PHENYLPYRIDIN-3-YL]ETHANOIC ACID
Descriptor:Integrase, (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid, SULFATE ION
Authors:Feng, L., Kvaratskhelia, M.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase.
Plos Pathog., 10, 2014
4O5B
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HIV-1 INTEGRASE CATALYTIC CORE DOMAIN COMPLEXED WITH ALLOSTERIC INHIBITOR (2S)-TERT-BUTOXY[6-(5-CHLORO-1H-BENZIMIDAZOL-2-YL)-2,5-DIMETHYL-4-PHENYLPYRIDIN-3-YL]ETHANOIC ACID
Descriptor:Integrase, (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid, SULFATE ION
Authors:Feng, L., Kvaratskhelia, M.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase.
Plos Pathog., 10, 2014
5HRN
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K MUTATION COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-23
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRP
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124T MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRR
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124N + T125S MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRS
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124N + T125A MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016