4OJR
Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264
Summary for 4OJR
Entry DOI | 10.2210/pdb4ojr/pdb |
Descriptor | HIV-1 Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, CACODYLATE ION, ... (5 entities in total) |
Functional Keywords | viral dna integration, dna binding, ledgf binding, viral protein |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 |
Total number of polymer chains | 1 |
Total formula weight | 18763.05 |
Authors | Gupta, K.,Brady, T.,Dyer, B.,Hwang, Y.,Male, F.,Nolte, R.T.,Wang, L.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.,Bushman, F.D. (deposition date: 2014-01-21, release date: 2014-06-11, Last modification date: 2024-02-28) |
Primary citation | Gupta, K.,Brady, T.,Dyer, B.M.,Malani, N.,Hwang, Y.,Male, F.,Nolte, R.T.,Wang, L.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D. Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS. J.Biol.Chem., 289:20477-20488, 2014 Cited by PubMed: 24904063DOI: 10.1074/jbc.M114.551119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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