4OJR
Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIV-1 Integrase | polymer | 164 | 17939.5 | 1 | UniProt (P03366) Pfam (PF00665) | Human immunodeficiency virus type 1 (HIV-1) | Integrase, IN |
| 2 | B (A) | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid | non-polymer | 453.5 | 1 | Chemie (2SQ) | |||
| 3 | C, D (A) | CACODYLATE ION | non-polymer | 137.0 | 2 | Chemie (CAC) | |||
| 4 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | F (A) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
| Lys 185 | Phe 1344 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17939.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 823.5 | |
| All* | Total formula weight | 18763.1 |
