HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002

Summary for 5HRN

Related5HOT 5HRP 5HRR 5HRS
DescriptorIntegrase, CACODYLATE ION, SULFATE ION, ... (6 entities in total)
Functional Keywordsviral dna integration, dna binding, ledgf binding, viral protein, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHuman immunodeficiency virus 1 (HIV-1)
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P04585
Total number of polymer chains1
Total molecular weight18968.28
Nolte, R.T. (deposition date: 2016-01-23, release date: 2016-12-14, Last modification date: 2016-12-21)
Primary citation
Gupta, K.,Turkki, V.,Sherrill-Mix, S.,Hwang, Y.,Eilers, G.,Taylor, L.,McDanal, C.,Wang, P.,Temelkoff, D.,Nolte, R.T.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D.
Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14:e1002584-e1002584, 2016
PubMed: 27935939 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pbio.1002584
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2282009.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report