8CT7

Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436

Summary for 8CT7

Entry DOI	10.2210/pdb8ct7/pdb
Descriptor	Integrase, (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	viral dna integration, dna binding, ledgf binding, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	18494.79
Authors	Gupta, K.,Van Duyne, G.D.,Eilers, G.,Bushman, F.D. (deposition date: 2022-05-13, release date: 2023-02-15, Last modification date: 2023-10-25)
Primary citation	Eilers, G.,Gupta, K.,Allen, A.,Montermoso, S.,Murali, H.,Sharp, R.,Hwang, Y.,Bushman, F.D.,Van Duyne, G. Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization. Plos Pathog., 19:e1011097-e1011097, 2023 Cited by PubMed: 36867659 DOI: 10.1371/journal.ppat.1011097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation