8CT7
Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrase | polymer | 161 | 17894.2 | 1 | UniProt (Q72498) Pfam (PF00665) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | B (A) | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid | non-polymer | 442.5 | 1 | Chemie (L3D) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E (A) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 50 - 210 (UniProt: Q72498)
| PDB | External Database | Details |
|---|---|---|
| Lys 185 | Phe 900 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17894.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 600.6 | |
| All* | Total formula weight | 18494.8 |
