8CTA

Minimal 2:2 Ternary Complex between BI-224436 bound HIV-1 Integrase Catalytic Core Domain Dimer and Carboxy Terminal Domains

Summary for 8CTA

• Entry DOI: 10.2210/pdb8cta/pdb
• Descriptor: Integrase, (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: viral dna integration, dna binding, ledgf binding, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 16
• Total formula weight: 195681.97

Authors

Gupta, K.,Van Duyne, G.D.,Eilers, G.,Bushman, F.D. (deposition date: 2022-05-13, release date: 2023-02-22, Last modification date: 2023-10-25)

• Primary citation: Eilers, G.,Gupta, K.,Allen, A.,Montermoso, S.,Murali, H.,Sharp, R.,Hwang, Y.,Bushman, F.D.,Van Duyne, G.; Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization.; Plos Pathog., 19:e1011097-e1011097, 2023; PubMed: 36867659; DOI: 10.1371/journal.ppat.1011097

Experimental method

X-RAY DIFFRACTION (2.93 Å)