Author results

6HVO
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THREE PEPTIDES OF P12 SUBUNIT OF HUMAN POLYMERASE DELTA
Descriptor:Proliferating cell nuclear antigen, DNA polymerase delta subunit 4, SULFATE ION
Authors:Gonzalez-Magana, A., Romano-Moreno, M., Rojas, A.L., Blanco, F.J., De Biasio, A.
Deposit date:2018-10-11
Release date:2019-01-23
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The p12 subunit of human polymerase delta uses an atypical PIP-box for molecular recognition of proliferating cell nuclear antigen (PCNA).
J. Biol. Chem., 2019
6GWS
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THREE P15 PEPTIDES
Descriptor:Proliferating cell nuclear antigen, PCNA-associated factor
Authors:De March, M., Merino, N., Gonzalez-Magana, A., Romano-Moreno, M., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2018-06-25
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
6GIS
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STRUCTURAL BASIS OF HUMAN CLAMP SLIDING ON DNA
Descriptor:Proliferating cell nuclear antigen, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3')
Authors:De March, M., Merino, N., Barrera-Vilarmau, S., Crehuet, R., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2018-05-15
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural basis of human PCNA sliding on DNA.
Nat Commun, 8, 2017
6FB0
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF CALCIUM
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*GP*AP*GP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB1
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF MAGNESIUM
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (3.024 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB2
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF MANGANESE
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB5
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) AT 5NNN REGION IN THE PRESENCE OF MAGNESIUM
Descriptor:I-CreI monomer A, I-CreI monomer B, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB6
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) AT 5NNN REGION IN THE PRESENCE OF MANGANESE
Descriptor:I-CreI monomer A, I-CreI monomer B, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*C)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB7
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MANGANESE
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.689 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB8
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA AT 5NNN REGION IN THE PRESENCE OF MAGNESIUM
Descriptor:DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP*GP*CP*AP*GP*TP*TP*TP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), DNA endonuclease I-CreI, ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB9
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA AT 5NNN REGION IN THE PRESENCE OF MANGANESE
Descriptor:DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*C)-3'), DNA endonuclease I-CreI, ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6EHT
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MODULATION OF PCNA SLIDING SURFACE BY P15PAF SUGGESTS A SUPPRESSIVE MECHANISM FOR CISPLATIN-INDUCED DNA LESION BYPASS BY POL ETA HOLOENZYME
Descriptor:Proliferating cell nuclear antigen, PCNA-associated factor, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), ...
Authors:De March, M., Barrera-Vilarmau, S., Mentegari, E., Merino, N., Bressan, E., Maga, G., Crehuet, R., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2017-09-15
Release date:2018-08-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
5MTO
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 C19S MUTANT
Descriptor:Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
Authors:Ormaza, G., Buitrago, J.A.R., Roversi, P., Rojas, A.L., Blanco, F.J.
Deposit date:2017-01-10
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:N-terminal domain of the human tumor suppressor ING5 C19S mutant
To Be Published
5ME8
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5
Descriptor:Inhibitor of growth protein 5, (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL
Authors:Roversi, P., Blanco, F.J., Rojas, A.L., Buitrago, J.A.R.
Deposit date:2016-11-14
Release date:2018-03-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The tumor suppressor ING5 is a dimeric molecule with Bivalent Recognition of the H3K4me3 mark
To Be Published
5HZW
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CRYSTAL STRUCTURE OF THE ORPHAN REGION OF HUMAN ENDOGLIN/CD105 IN COMPLEX WITH BMP9
Descriptor:Maltose-binding periplasmic protein,Endoglin, Growth/differentiation factor 2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bokhove, M., Saito, T., Jovine, L.
Deposit date:2016-02-03
Release date:2017-06-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (4.451 Å)
Cite:Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Cell Rep, 19, 2017
5I04
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CRYSTAL STRUCTURE OF THE ORPHAN REGION OF HUMAN ENDOGLIN/CD105
Descriptor:Maltose-binding periplasmic protein,Endoglin, N-ACETYL-D-GLUCOSAMINE, MALTOSE, ...
Authors:Saito, T., Bokhove, M., de Sanctis, D., Jovine, L.
Deposit date:2016-02-03
Release date:2017-06-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Cell Rep, 19, 2017
5A77
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA CLEAVED
Descriptor:DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*DCP)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A78
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA NOT CLEAVED
Descriptor:DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP *CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A72
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM CA
Descriptor:DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*DTP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP *DCP*GP*AP*CP*GP*TP*TP*CP*TP*GP*A)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A74
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM MN
Descriptor:DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
4ZTD
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH A TRAIP PEPTIDE
Descriptor:Proliferating cell nuclear antigen, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, ALA-GLY-ALA-GLY-ALA
Authors:Montoya, G., Mortuza, G.B., Blanco, F.J., Ibanez de Opakua, A.
Deposit date:2015-05-14
Release date:2015-12-16
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
J.Cell Biol., 212, 2016
5A0M
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THE CRYSTAL STRUCTURE OF I-SCEI IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MN
Descriptor:INTRON-ENCODED ENDONUCLEASE I-SCEI, 5'-D(*CP*AP*CP*GP*CP*TP*AP*GP*GP*GP*AP*TP*AP*AP)-3', 5'-D(*GP*GP*TP*AP*TP*TP*AP*CP*CP*CP*TP*GP*TP*TP *AP*TP)-3', ...
Authors:Prieto, J., Redondo, P., Merino, N., Villate, M., Blanco, F.J., Molina, R.
Deposit date:2015-04-21
Release date:2016-05-04
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the I-Scei Nuclease Complexed with its DsDNA Target and Three Catalytic Metal Ions.
Acta Crystallogr.,Sect.F, 72, 2016
4D2G
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH P15 PEPTIDE
Descriptor:PROLIFERATING CELL NUCLEAR ANTIGEN, P15
Authors:DeBiasio, A., Ibanez, A., Mortuza, G., Molina, R., Cordeiro, T.N., Castillo, F., Villate, M., Merino, N., Lelli, M., Diercks, T., Luque, I., Bernardo, P., Montoya, G., Blanco, F.J.
Deposit date:2014-05-09
Release date:2015-03-18
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of P15(Paf)-PCNA Complex and Implications for Clamp Sliding During DNA Replication and Repair.
Nat.Commun., 6, 2015
2M1R
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PHD DOMAIN OF ING4 N214D MUTANT
Descriptor:Inhibitor of growth protein 4, ZINC ION
Authors:Blanco, F.J.
Deposit date:2012-12-05
Release date:2012-12-26
Method:SOLUTION NMR
Cite:Functional impact of cancer-associated mutations in the tumor suppressor protein ING4.
Carcinogenesis, 31, 2010
4AFL
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THE CRYSTAL STRUCTURE OF THE ING4 DIMERIZATION DOMAIN REVEALS THE FUNCTIONAL ORGANIZATION OF THE ING FAMILY OF CHROMATIN BINDING PROTEINS.
Descriptor:INHIBITOR OF GROWTH PROTEIN 4
Authors:Culurgioni, S., Munoz, I.G., Moreno, A., Palacios, A., Villate, M., Palmero, I., Montoya, G., Blanco, F.J.
Deposit date:2012-01-19
Release date:2012-02-22
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.275 Å)
Cite:Crystal Structure of Inhibitor of Growth 4 (Ing4) Dimerization Domain Reveals Functional Organization of Ing Family of Chromatin-Binding Proteins.
J.Biol.Chem., 287, 2012
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