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4ZS7
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BU of 4zs7 by Molmil
Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
Descriptor: Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain
Authors:Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
2RLZ
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BU of 2rlz by Molmil
Solid-State MAS NMR structure of the dimer Crh
Descriptor: HPr-like protein crh
Authors:Loquet, A, Bardiaux, B, Gardiennet, C, Blanchet, C, Baldus, M, Nilges, M, Malliavin, T, Bockmann, A.
Deposit date:2007-09-04
Release date:2008-06-17
Last modified:2024-05-29
Method:SOLID-STATE NMR
Cite:3D structure determination of the Crh protein from highly ambiguous solid-state NMR restraints.
J.Am.Chem.Soc., 130, 2008
4R96
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BU of 4r96 by Molmil
Structure of a Llama Glama Fab 48A2 against human cMet
Descriptor: Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
4O9H
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BU of 4o9h by Molmil
Structure of Interleukin-6 in complex with a Camelid Fab fragment
Descriptor: Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7
Authors:Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C.
Deposit date:2014-01-02
Release date:2015-04-15
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
4R90
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BU of 4r90 by Molmil
Anti CD70 Llama glama Fab 27B3
Descriptor: Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ...
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
6HXM
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BU of 6hxm by Molmil
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH in space group C2221
Descriptor: ATP-citrate synthase, CITRATE ANION, COENZYME A
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6VIF
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BU of 6vif by Molmil
Human LRH-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator TIF-2
Descriptor: N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6:7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric diamide, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2
Authors:Cato, M.L, Ortlund, E.A.
Deposit date:2020-01-13
Release date:2020-06-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition.
Bioorg.Med.Chem.Lett., 30, 2020
6QCL
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BU of 6qcl by Molmil
Citryl-CoA lyase core module of Chlorobium limicola ATP citrate lyase in complex with acetyl-CoA and L-malate
Descriptor: (2S)-2-hydroxybutanedioic acid, ACETYL COENZYME *A, ATP-citrate lyase alpha-subunit, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-12-28
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6QFB
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BU of 6qfb by Molmil
Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, CITRATE ANION, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2019-01-09
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXJ
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BU of 6hxj by Molmil
Structure of ATP citrate lyase from Chlorobium limicola in complex with citrate and coenzyme A.
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-citrate lyase alpha-subunit, ATP-citrate lyase beta-subunit, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXI
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BU of 6hxi by Molmil
Structure of ATP citrate lyase from Methanothrix soehngenii in complex with citrate and coenzyme A
Descriptor: ACETATE ION, CITRATE ANION, COENZYME A, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXO
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BU of 6hxo by Molmil
Structure of the citryl-CoA lyase core module of Chlorobium limicola ATP citrate lyase (space group P21)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ATP-citrate lyase alpha-subunit, CITRATE ANION
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXP
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BU of 6hxp by Molmil
Structure of citryl-CoA lyase from Hydrogenobacter thermophilus
Descriptor: COENZYME A, Citryl-CoA lyase, SULFATE ION
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXN
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BU of 6hxn by Molmil
Structure of the citryl-CoA lyase core module of Chlorobium limicola ATP citrate lyase (space group P3121)
Descriptor: ATP-citrate lyase alpha-subunit, COENZYME A, SULFATE ION
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXK
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BU of 6hxk by Molmil
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate
Descriptor: 1,2-ETHANEDIOL, ATP-citrate synthase, CITRATE ANION, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXH
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BU of 6hxh by Molmil
Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase,Human ATP citrate lyase, CITRATE ANION, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXL
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BU of 6hxl by Molmil
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH (space group P21)
Descriptor: 1,2-ETHANEDIOL, ATP-citrate synthase, CITRATE ANION, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXQ
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BU of 6hxq by Molmil
Structure of citryl-CoA synthetase from Hydrogenobacter thermophilus
Descriptor: CITRATE ANION, COENZYME A, Citryl-CoA synthetase large subunit, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6QRN
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BU of 6qrn by Molmil
Galectin-10 complexed with ribose
Descriptor: Galectin-10, beta-D-ribopyranose
Authors:Verstraete, K, Verschueren, K.H.G.
Deposit date:2019-02-19
Release date:2019-06-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GLX
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BU of 6glx by Molmil
Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 4E8
Descriptor: Fab 4E8 - Heavy chain, Fab 4E8 - Light chain, Galectin-10
Authors:Verstraete, K, Verschueren, K, Savvides, S.N.
Deposit date:2018-05-23
Release date:2019-06-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
7OX6
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BU of 7ox6 by Molmil
Solution structure of human interleukin-9
Descriptor: Interleukin-9
Authors:Savvides, S.N, Tripsianes, K, De Vos, T, Papageorgiou, A, Evangelidis, T.
Deposit date:2021-06-22
Release date:2022-12-28
Last modified:2023-01-11
Method:SOLUTION NMR
Cite:Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
7OX5
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BU of 7ox5 by Molmil
hIL-9:hIL-9Ra complex
Descriptor: Interleukin-9, Interleukin-9 receptor, SULFATE ION
Authors:De Vos, T, Savvides, S.N.
Deposit date:2021-06-22
Release date:2022-12-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
7OX4
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BU of 7ox4 by Molmil
Mouse interleukin-9 in complex with Fab 35D8.
Descriptor: ACETATE ION, Heavy chain (Fab 35D8), Interleukin-9, ...
Authors:De Vos, T, Savvides, S.N.
Deposit date:2021-06-22
Release date:2022-12-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
7OX3
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BU of 7ox3 by Molmil
Fab 6D3: hIL-9 complex
Descriptor: Heavy chain (Fab 6D3), Interleukin-9, Light chain (Fab 6D3), ...
Authors:De Vos, T, Savvides, S.N.
Deposit date:2021-06-22
Release date:2022-12-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
7OX2
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BU of 7ox2 by Molmil
Fab 6E2: hIL-9 complex
Descriptor: Heavy chain (Fab 6E2), Interleukin-9, Light chain (Fab 6E2), ...
Authors:De Vos, T, Savvides, S.N.
Deposit date:2021-06-22
Release date:2022-12-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022

 

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