4ZS7

Structural mimicry of receptor interaction by antagonistic IL-6 antibodies

Summary for 4ZS7

Entry DOI	10.2210/pdb4zs7/pdb
Descriptor	Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain, ... (4 entities in total)
Functional Keywords	interleukine 6 complex, fab fragment, dromedery, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P05231
Total number of polymer chains	3
Total formula weight	66442.40
Authors	Blanchetot, C.,De Jonge, N.,Desmyter, A.,Ongenae, N.,Hofman, E.,Klarenbeek, A.,Sadi, A.,Hultberg, A.,Kretz-Rommel, A.,Spinelli, S.,Loris, R.,Cambillau, C.,de Haard, H. (deposition date: 2015-05-13, release date: 2016-05-04, Last modification date: 2016-07-06)
Primary citation	Blanchetot, C.,De Jonge, N.,Desmyter, A.,Ongenae, N.,Hofman, E.,Klarenbeek, A.,Sadi, A.,Hultberg, A.,Kretz-Rommel, A.,Spinelli, S.,Loris, R.,Cambillau, C.,de Haard, H. Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies. J.Biol.Chem., 291:13846-13854, 2016 Cited by PubMed: 27129274 DOI: 10.1074/jbc.M115.695528 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.93 Å)

Structure validation