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4ZS7

Structural mimicry of receptor interaction by antagonistic IL-6 antibodies

Functional Information from GO Data
ChainGOidnamespacecontents
A0001781biological_processneutrophil apoptotic process
A0002314biological_processgerminal center B cell differentiation
A0002384biological_processhepatic immune response
A0002446biological_processneutrophil mediated immunity
A0002548biological_processmonocyte chemotaxis
A0002639biological_processpositive regulation of immunoglobulin production
A0002675biological_processpositive regulation of acute inflammatory response
A0002690biological_processpositive regulation of leukocyte chemotaxis
A0005125molecular_functioncytokine activity
A0005138molecular_functioninterleukin-6 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005788cellular_componentendoplasmic reticulum lumen
A0005896cellular_componentinterleukin-6 receptor complex
A0006953biological_processacute-phase response
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0006959biological_processhumoral immune response
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0010573biological_processvascular endothelial growth factor production
A0010574biological_processregulation of vascular endothelial growth factor production
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010628biological_processpositive regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010888biological_processnegative regulation of lipid storage
A0014823biological_processresponse to activity
A0019221biological_processcytokine-mediated signaling pathway
A0030154biological_processcell differentiation
A0030168biological_processplatelet activation
A0031018biological_processendocrine pancreas development
A0031175biological_processneuron projection development
A0032494biological_processresponse to peptidoglycan
A0032682biological_processnegative regulation of chemokine production
A0032722biological_processpositive regulation of chemokine production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032733biological_processpositive regulation of interleukin-10 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032745biological_processpositive regulation of interleukin-21 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032966biological_processnegative regulation of collagen biosynthetic process
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0035633biological_processmaintenance of blood-brain barrier
A0042102biological_processpositive regulation of T cell proliferation
A0042593biological_processglucose homeostasis
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043410biological_processpositive regulation of MAPK cascade
A0045599biological_processnegative regulation of fat cell differentiation
A0045669biological_processpositive regulation of osteoblast differentiation
A0045727biological_processpositive regulation of translation
A0045765biological_processregulation of angiogenesis
A0045779biological_processnegative regulation of bone resorption
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050768biological_processnegative regulation of neurogenesis
A0050796biological_processregulation of insulin secretion
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0050871biological_processpositive regulation of B cell activation
A0051223biological_processregulation of protein transport
A0051251biological_processpositive regulation of lymphocyte activation
A0051384biological_processresponse to glucocorticoid
A0051607biological_processdefense response to virus
A0060252biological_processpositive regulation of glial cell proliferation
A0061470biological_processT follicular helper cell differentiation
A0061888biological_processregulation of astrocyte activation
A0070050biological_processneuron cellular homeostasis
A0070091biological_processglucagon secretion
A0070092biological_processregulation of glucagon secretion
A0070102biological_processinterleukin-6-mediated signaling pathway
A0070301biological_processcellular response to hydrogen peroxide
A0071222biological_processcellular response to lipopolysaccharide
A0072540biological_processT-helper 17 cell lineage commitment
A0072574biological_processhepatocyte proliferation
A0090091biological_processpositive regulation of extracellular matrix disassembly
A0090594biological_processinflammatory response to wounding
A0097421biological_processliver regeneration
A0097696biological_processcell surface receptor signaling pathway via STAT
A0098586biological_processcellular response to virus
A0150077biological_processregulation of neuroinflammatory response
A0150078biological_processpositive regulation of neuroinflammatory response
A1900017biological_processpositive regulation of cytokine production involved in inflammatory response
A1901731biological_processpositive regulation of platelet aggregation
A1902512biological_processpositive regulation of apoptotic DNA fragmentation
A1902895biological_processpositive regulation of miRNA transcription
A1903978biological_processregulation of microglial cell activation
A1904894biological_processpositive regulation of receptor signaling pathway via STAT
A1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
A2000553biological_processpositive regulation of T-helper 2 cell cytokine production
A2000635biological_processnegative regulation of primary miRNA processing
A2000660biological_processnegative regulation of interleukin-1-mediated signaling pathway
A2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00254
Number of Residues26
DetailsINTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL
ChainResidueDetails
ACYS73-LEU98

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
ChainResidueDetails
LTYR195-HIS201
HTYR203-HIS209

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
ASER53

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1883960
ChainResidueDetails
AASN45

237423

PDB entries from 2025-06-11

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