6HXL

Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH (space group P21)

Summary for 6HXL

• Entry DOI: 10.2210/pdb6hxl/pdb
• Descriptor: ATP-citrate synthase, COENZYME A, CITRATE ANION, ... (8 entities in total)
• Functional Keywords: atp citrate lyase, central metabolism, acetyl-coa, citrate shuttle, rtca cycle, citryl-coa, lipogenesis, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 247632.41

Authors

Verstraete, K.,Verschueren, K. (deposition date: 2018-10-17, release date: 2019-04-10, Last modification date: 2019-05-08)

• Primary citation: Verschueren, K.H.G.,Blanchet, C.,Felix, J.,Dansercoer, A.,De Vos, D.,Bloch, Y.,Van Beeumen, J.,Svergun, D.,Gutsche, I.,Savvides, S.N.,Verstraete, K.; Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.; Nature, 568:571-575, 2019; PubMed: 30944476; DOI: 10.1038/s41586-019-1095-5

Experimental method

X-RAY DIFFRACTION (1.35 Å)