Author results

5A35
  • Download 5a35
  • View 5a35
Molmil generated image of 5a35
CRYSTAL STRUCTURE OF GLYCINE CLEAVAGE PROTEIN H-LIKE (GCVH-L) FROM STREPTOCOCCUS PYOGENES
Descriptor:GLYCINE CLEAVAGE SYSTEM H PROTEIN, PENTAETHYLENE GLYCOL
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-27
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
5A3A
  • Download 5a3a
  • View 5a3a
Molmil generated image of 5a3a
CRYSTAL STRUCTURE OF THE ADP-RIBOSYLATING SIRTUIN (SIRTM) FROM STREPTOCOCCUS PYOGENES (APO FORM)
Descriptor:SIR2 FAMILY PROTEIN, GLYCINE, ZINC ION, ...
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-28
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
5A3B
  • Download 5a3b
  • View 5a3b
Molmil generated image of 5a3b
CRYSTAL STRUCTURE OF THE ADP-RIBOSYLATING SIRTUIN (SIRTM) FROM STREPTOCOCCUS PYOGENES IN COMPLEX WITH ADP-RIBOSE
Descriptor:SIR2 FAMILY PROTEIN, GLYCINE, ALANINE, ...
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-28
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
5A3C
  • Download 5a3c
  • View 5a3c
Molmil generated image of 5a3c
CRYSTAL STRUCTURE OF THE ADP-RIBOSYLATING SIRTUIN (SIRTM) FROM STREPTOCOCCUS PYOGENES IN COMPLEX WITH NAD
Descriptor:SIR2 FAMILY PROTEIN, GLYCINE, ZINC ION, ...
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-28
Release date:2015-07-29
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
5A7R
  • Download 5a7r
  • View 5a7r
Molmil generated image of 5a7r
HUMAN POLY(ADP-RIBOSE) GLYCOHYDROLASE IN COMPLEX WITH SYNTHETIC DIMERIC ADP-RIBOSE
Descriptor:POLY(ADP-RIBOSE) GLYCOHYDROLASE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, BETA-MERCAPTOETHANOL, ...
Authors:Lambrecht, M.J., Brichacek, M., Barkauskaite, E., Ariza, A., Ahel, I., Hergenrother, P.J.
Deposit date:2015-07-09
Release date:2015-07-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synthesis of Dimeric Adp-Ribose and its Structure with Human Poly(Adp-Ribose) Glycohydrolase.
J.Am.Chem.Soc., 137, 2015
4L2H
  • Download 4l2h
  • View 4l2h
Molmil generated image of 4l2h
STRUCTURE OF A CATALYTICALLY INACTIVE PARG IN COMPLEX WITH A POLY-ADP-RIBOSE FRAGMENT
Descriptor:Poly(ADP-ribose) glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Brassington, A., Dunstan, M.S., Leys, D.
Deposit date:2013-06-04
Release date:2013-07-24
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.
Nat Commun, 4, 2013
6HMK
  • Download 6hmk
  • View 6hmk
Molmil generated image of 6hmk
POLYADPRIBOSYL GLYCOHYDROLASE IN COMPLEX WITH PDD00016690
Descriptor:Poly(ADP-ribose) glycohydrolase, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Tucker, J.A., Barkauskaite, E.
Deposit date:2018-09-12
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J. Med. Chem., 2018
6HML
  • Download 6hml
  • View 6hml
Molmil generated image of 6hml
POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00017299
Descriptor:Poly(ADP-ribose) glycohydrolase, 1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-6-[[(1-methylcyclopropyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-3-[(1-methylpyrazol-4-yl)methyl]quinazoline-2,4-dione, DIMETHYL SULFOXIDE, ...
Authors:Tucker, J.A., Barkauskaite, E.
Deposit date:2018-09-12
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J. Med. Chem., 2018
3SIG
  • Download 3sig
  • View 3sig
Molmil generated image of 3sig
THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) BOUND TO ADP-RIBOSE FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Leys, D., Dunstan, M.S.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
3SIH
  • Download 3sih
  • View 3sih
Molmil generated image of 3sih
THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase
Authors:Dunstan, M.S., Leys, D.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
3SII
  • Download 3sii
  • View 3sii
Molmil generated image of 3sii
THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE BOUND TO THE INHIBITOR ADP-HPD FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE
Authors:Dunstan, M.S., Leys, D.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
3SIJ
  • Download 3sij
  • View 3sij
Molmil generated image of 3sij
THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE E115A MUTANT FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase
Authors:Dunstan, M.S., Leys, D.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
4EPP
  • Download 4epp
  • View 4epp
Molmil generated image of 4epp
CANONICAL POLY(ADP-RIBOSE) GLYCOHYDROLASE FROM TETRAHYMENA THERMOPHILA.
Descriptor:Poly(ADP-ribose) glycohydrolase, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Dunstan, M.S., Leys, D.
Deposit date:2012-04-17
Release date:2012-06-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase.
Nat Commun, 3, 2012
4EPQ
  • Download 4epq
  • View 4epq
Molmil generated image of 4epq
CANONICAL POLY(ADP-RIBOSE) GLYCOHYDROLASE RBPI INHIBITOR COMPLEX FROM TETRAHYMENA THERMOPHILA
Descriptor:Poly(ADP-ribose) glycohydrolase, 3-{(5Z)-5-[5-chloro-1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}propanoic acid
Authors:Dunstan, M.S., Leys, D.
Deposit date:2012-04-17
Release date:2012-06-13
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase.
Nat Commun, 3, 2012
5LHB
  • Download 5lhb
  • View 5lhb
Molmil generated image of 5lhb
POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00017262
Descriptor:Poly(ADP-ribose) glycohydrolase, 1-(cyclopropylmethyl)-6-[[(1-methylcyclopropyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-3-[(2-methyl-1,3-thiazol-5-yl)methyl]quinazoline-2,4-dione, SULFATE ION, ...
Authors:Tucker, J., Barkauskaite, E.
Deposit date:2016-07-10
Release date:2016-10-12
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
ACS Chem. Biol., 11, 2016
5LW6
  • Download 5lw6
  • View 5lw6
Molmil generated image of 5lw6
CRYSTAL STRUCTURE OF A SE-MET SUBSTITUTED DICTYOSTELIUM DISCOIDEUM ADP-RIBOSE BINDING MACRODOMAIN (RESIDUES 342-563) OF DDB_G0293866
Descriptor:DDB_G0293866
Authors:Leys, D., Barkauskaite, E., Pinero, B.B., Ahel, I.
Deposit date:2016-09-15
Release date:2016-09-28
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The role of ADP-ribosylation in regulating DNA interstrand crosslink repair.
J.Cell.Sci., 129, 2016