5A3C

Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with NAD

Summary for 5A3C

Related5A35 5A3A 5A3B
DescriptorSIR2 FAMILY PROTEIN, GLYCINE, ZINC ION, ... (6 entities in total)
Functional Keywordstransferase, adp-ribosyltransferase, metalloprotein, nad-dependent, lipoylation, regulatory enzyme, rossmann fold, zinc binding, ros defense
Biological sourceSTREPTOCOCCUS PYOGENES
Total number of polymer chains1
Total molecular weight36234.75
Authors
Rack, J.G.M.,Morra, R.,Barkauskaite, E.,Kraehenbuehl, R.,Ariza, A.,Qu, Y.,Ortmayer, M.,Leidecker, O.,Cameron, D.R.,Matic, I.,Peleg, A.Y.,Leys, D.,Traven, A.,Ahel, I. (deposition date: 2015-05-28, release date: 2015-07-29, Last modification date: 2015-10-07)
Primary citation
Rack, J.G.,Morra, R.,Barkauskaite, E.,Kraehenbuehl, R.,Ariza, A.,Qu, Y.,Ortmayer, M.,Leidecker, O.,Cameron, D.R.,Matic, I.,Peleg, A.Y.,Leys, D.,Traven, A.,Ahel, I.
Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59:309-, 2015
PubMed: 26166706 (PDB entries with the same primary citation)
DOI: 10.1016/J.MOLCEL.2015.06.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.03 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24020 1.6% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-28