5A3C

Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with NAD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SIR2 FAMILY PROTEIN	polymer	303	35156.6	1	UniProt (Q1JGN6) In PDB	STREPTOCOCCUS PYOGENES	ADP-RIBOSYLATING SIRTUIN, SIRTM
2	A	GLYCINE	non-polymer		75.1	3	Chemie (GLY)
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	1	Chemie (NAD)
5	A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6		water	water		18.0	157	Chemie (HOH)

Sequence modifications

A: 1 - 293 (UniProt: Q1JGN6)

PDB	External Database	Details
Met -9	-	expression tag
Gly -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35156.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1078.2
All*	Total formula weight	36234.8

*Water molecules are not included.