5A3C

Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006471	biological_process	obsolete protein ADP-ribosylation
A	0008270	molecular_function	zinc ion binding
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0070403	molecular_function	NAD+ binding
A	0140806	molecular_function	NAD+-protein-aspartate ADP-ribosyltransferase activity
A	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1293

Chain	Residue
A	CYS145
A	CYS149
A	CYS180
A	CYS183

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site_id	AC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAD A 1294

Chain	Residue
A	THR117
A	ASN118
A	ALA119
A	ASP120
A	GLN137
A	TYR140
A	GLY229
A	VAL230
A	GLY231
A	HIS232
A	THR233
A	THR234
A	ASN258
A	HIS259
A	LYS260
A	TYR262
A	HIS278
A	ILE279
A	HOH2010
A	HOH2015
A	HOH2060
A	HOH2072
A	HOH2123
A	GLY33
A	ALA34
A	GLY35
A	ALA39
A	TYR44

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1295

Chain	Residue
A	TYR79
A	GLN144
A	GLU188
A	ILE189
A	LYS191

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1296

Chain	Residue
A	ASP72
A	PHE73
A	ASP75
A	TRP76
A	TYR79

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site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GLY A 1297

Chain	Residue
A	TYR60
A	GLN61
A	PHE62
A	GLN67
A	PHE71
A	TRP124

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GLY A 1298

Chain	Residue
A	ASP75
A	TRP76
A	GLN77

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site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GLY A 1299

Chain	Residue
A	LYS110
A	ASP111
A	TYR112
A	ASN132
A	PHE214
A	HOH2054
A	HOH2057
A	HOH2125

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