5LHB

POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00017262

Summary for 5LHB

• Entry DOI: 10.2210/pdb5lhb/pdb
• Descriptor: Poly(ADP-ribose) glycohydrolase, 1-(cyclopropylmethyl)-6-[[(1-methylcyclopropyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-3-[(2-methyl-1,3-thiazol-5-yl)methyl]quinazoline-2,4-dione, SULFATE ION, ... (5 entities in total)
• Functional Keywords: hydrolase, competitive inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 62081.67

Authors

Tucker, J.,Barkauskaite, E. (deposition date: 2016-07-10, release date: 2016-10-12, Last modification date: 2024-01-10)

• Primary citation: James, D.I.,Smith, K.M.,Jordan, A.M.,Fairweather, E.E.,Griffiths, L.A.,Hamilton, N.S.,Hitchin, J.R.,Hutton, C.P.,Jones, S.,Kelly, P.,McGonagle, A.E.,Small, H.,Stowell, A.I.,Tucker, J.,Waddell, I.D.,Waszkowycz, B.,Ogilvie, D.J.; First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.; ACS Chem. Biol., 11:3179-3190, 2016; PubMed: 27689388; DOI: 10.1021/acschembio.6b00609

Experimental method

X-RAY DIFFRACTION (2.23 Å)