5A7R

Human poly(ADP-ribose) glycohydrolase in complex with synthetic dimeric ADP-ribose

Summary for 5A7R

Entry DOI	10.2210/pdb5a7r/pdb
Descriptor	POLY(ADP-RIBOSE) GLYCOHYDROLASE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, BETA-MERCAPTOETHANOL, ... (7 entities in total)
Functional Keywords	hydrolase, parg, adp-ribose
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 1: Nucleus . Isoform 2: Cytoplasm . Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Isoform 5: Mitochondrion matrix: Q86W56
Total number of polymer chains	1
Total formula weight	64255.96
Authors	Lambrecht, M.J.,Brichacek, M.,Barkauskaite, E.,Ariza, A.,Ahel, I.,Hergenrother, P.J. (deposition date: 2015-07-09, release date: 2015-07-22, Last modification date: 2024-01-10)
Primary citation	Lambrecht, M.J.,Brichacek, M.,Barkauskaite, E.,Ariza, A.,Ahel, I.,Hergenrother, P.J. Synthesis of Dimeric Adp-Ribose and its Structure with Human Poly(Adp-Ribose) Glycohydrolase. J.Am.Chem.Soc., 137:3558-, 2015 Cited by PubMed: 25706250 DOI: 10.1021/JA512528P PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation